What does thymic stromal Lymphopoietin do?

Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells.

What is TSLP inflammation?

Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis.

Where is TSLP produced?

TSLP is produced predominantly by airways and nasal epithelial cells and by skin keratinocytes and also stimulates immature myeloid dendritic cells, which express the heterodimeric TSLP receptor to differentiate into mature dendritic cells.

What produces TSLP?

Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and keratinocytes, and is involved in immune homeostasis or inflammation.

What is TSLP in asthma?

Abstract. Thymic stromal lymphopoietin (TSLP) is an allarmin cytokine whose importance in human asthma has been repeatedly documented. Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma.

What kind of immune system cells develop in the thymus?

The developing progenitors within the thymus, also known as thymocytes, undergo a series of maturation steps that can be identified based on the expression of different cell surface markers. The majority of cells in the thymus give rise to αβ T cells, however approximately 5% bear the γδ T cell receptor (TCR).

How do you treat TSLP?

TSLP has been implicated in asthma pathophysiology. Tezepelumab is a first-in-class human monoclonal antibody that binds to TSLP, thus inhibiting its interaction with TSLP receptor complex. Tezepelumab given as an add-on-therapy to patients with severe uncontrolled asthma has shown safety, tolerability and efficacy.

Who owns Tezepelumab?

Tezepelumab is being developed by AstraZeneca in collaboration with Amgen (see AstraZeneca and Amgen collaboration below). Asthma is a complex and heterogeneous disease affecting an estimated 339 million people worldwide. Approximately 10% of asthma patients have severe asthma.

How do you treat Tslp?

What is the major difference between B cells and T cells?

An important difference between T-cells and B-cells is that B-cells can connect to antigens right on the surface of the invading virus or bacteria. This is different from T-cells, which can only connect to virus antigens on the outside of infected cells. Your body has up to 10 billion different B-cells.

What does thymus do in the immune system?

The thymus makes white blood cells called T lymphocytes (also called T cells). These are an important part of the body’s immune system, which helps us to fight infection. The thymus produces all our T cells before we become teenagers.

What is the role of thymic stromal lymphopoietin?

Thymic stromal lymphopoietin. Thymic stromal lymphopoietin ( TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells . TSLP is produced mainly by non- hematopoietic cells such as fibroblasts,…

How is TSLP produced in hematopoietic T cells?

It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells . TSLP is produced mainly by non- hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells.

Where are thymically originating regulatory T cells located?

TSLP may induce thymically originating regulatory T cells, by being expressed by the epithelial cells present in the thymic tissue. Centrally produced Treg cells have similar roles to those produced in the periphery – most commonly in the gut, but are still important players in maintaining human tolerance.

Where does TSLP come from in the body?

TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells.

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