What are the disadvantages of a randomized controlled trial?

Disadvantages of randomised control trial study design

• Trials which test for efficacy may not be widely applicable. Trials which test for effectiveness are larger and more expensive.
• Results may not always mimic real life treatment situation (e.g. inclusion / exclusion criteria; highly controlled setting)

What is a multicenter study design?

A clinical trial conducted that follows a single protocol but is conducted in more than one place and, consequently, by more than one investigator. Adapted from Good Clinical Practices. Pan American Health Organization.

What are the pros and cons of multicentre research?

Multicentre collaboration can result in higher rates of patient enrolment than single-centre trials, thereby generating larger studies of shorter duration.

What are the benefits of a multicenter clinical trial?

International Multicenter Clinical Trials: Benefits and Challenges. An international multicenter clinical trial is a joint research effort that involves more than one clinical center, and more than one country to recruit and treat subjects.

Are there any disadvantages to using nuclear energy?

In spite of its many benefits, nuclear energy often falls under fire because of the many disadvantages it brings. That’s not to say that nuclear energy is not useful; we are just pointing out the risks that are also involved. Here are ten disadvantages of nuclear energy that we have seen. 1. Raw Materials

Which is a weakness of the multicenter study?

The multicenter approach is a weakness of the present study together with the relative low number of patients that were evaluated for inclusion, which might be a confounder [28]. Another weakness is that the treatment was carried out mainly by junior surgical residents, operating under everyday emergency conditions.