What is c-Myc promoter?

The transcription factor c-Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c-myc expression possesses a high transformation potential and the proto-oncogene c-myc represents a promising target in anticancer therapy.

What is the role of c-Myc?

c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.

How is MYC regulated?

Myc transcriptional activity is regulated by phosphorylation at Ser-62 followed by Thr-58, and subsequent proteasomal degradation after performing its function (Salghetti et al., 1999; Thomas and Tansey, 2010)(Adhikary et al., 2005; Popov et al., 2010; Popov et al., 2007).

What is the MYC pathway?

The MYC gene belongs to an oncogene encoding a nuclear protein that encodes a nuclear DNA binding protein involved in cell cycle regulation. The MYC gene family and its products promote cell proliferation, immortalization, dedifferentiation and transformation.

How is c-Myc related to cellular proliferation?

Atthesametime,c-Mycoverexpressionresultsincoordinatedchangesinlevelofexpressionofgenefamilies which result in increased cellular proliferation. This interesting duality of c-Myc effects places it in the mainstream of transformational changes and gives it a very important role in regulating the “transformed phenotype.”

Which is characteristic of over expression of c Myc?

Over expression of c-myc is characteristic of many cancers. Conversion of c Myc proto oncogene can occur via different mechanisms such as translocation under constitutive active promoter • Oncogenes that encode products that affect Apoptosis Apoptosis is process of distruction of cancerous cells.

How does conversion of c myc proto oncogene occur?

Conversion of c Myc proto oncogene can occur via different mechanisms such as translocation under constitutive active promoter • Oncogenes that encode products that affect Apoptosis Apoptosis is process of distruction of cancerous cells. Inability to carry on apoptosis can result in tumor e.g., Bcl2 proto oncogene

How does cMyc help in the development of cancer?

Please try again later. cmyc oncogene helps in the development of cancer by modifying the cell growth and proliferation pathways. http://shomusbiology.com/bio-material…