What does CCL19 and CCL21 do?

CCL19/CCL21 and CCR7 are well-known to be essential for fulfilling the important role of recruiting T cells into the lung and other peripheral specialized microenvironments within tissues (important pathogen entry sites).

What are CCL19 CCL21 and CCR7?

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs.

What is the role of chemokines in inflammation?

Inflammatory chemokines control the recruitment of effector leucocytes in infection, inflammation, tissue injury, and tumours. Many of the inflammatory chemokines have broad target cell selectivity and act on cells of the innate as well as the adaptive immune system.

What produces CCL19?

CCL19 is produced primarily by stromal cells in the thymus and by the T cell area of secondary lymphoid tissues (1, 6). CCL21-Ser is produced by stromal cells in the T cell area and by the high endothelial venules of the secondary lymphoid tissues, CCL21-Leu by the lymphatic endothelium alone (1).

What is the function of the CCL19 gene?

Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene. This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes.

Where are CXCL13 and CCL19 produced in the body?

In homeostasis, CXCL13 is produced by high endothelial venules and by the follicular dendritic cells in B cell follicles. The homing receptor CCR7 binds two chemokines CCL19 and CCL21 and is a key regulator for migration of leukocytes, such as dendritic cells]

How does CCL19 and CCR7 affect viral pathogenesis?

In this review, we summarize the impacts of CCL19 and CCR7 expression on the regulation of viral pathogenesis with an emphasis on the corresponding signaling pathways and adjuvant mechanisms.

What is the role of chemokine ligand 19?

Chemokine (C–C motif) ligand 19 (CCL19) is a critical regulator of the induction of T cell activation, immune tolerance, and inflammatory responses during continuous immune surveillance, homeostasis, and development.