What causes axonal degeneration?

Axon degeneration is a hallmark consequence of chemical neurotoxicant exposure (e.g. acrylamide), mechanical trauma (e.g. nerve transection, spinal cord contusion), deficient perfusion (e.g. ischemia, hypoxia), and inherited neuropathies (e.g. infantile neuroaxonal dystrophy).

What does axonal transport do?

Axonal transport is the process by which nerve cells transfer substances between the cell body and axon tip. Axonal means anything relating to an axon. Cargoes can be delivered in two directions.

What is axonal disease?

Giant axonal neuropathy is an inherited condition characterized by abnormally large and dysfunctional axons called giant axons. Axons are specialized extensions of nerve cells (neurons) that transmit nerve impulses.

Which is a characteristic feature of axonal neuropathy?

Axonal neuropathy, a characteristic feature of this condition, is caused by damage to a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses.

What causes autosomal recessive axonal neuropathy with neuromyotonia?

Autosomal recessive axonal neuropathy with neuromyotonia is caused by mutations in the HINT1 gene. This gene provides instructions for making a protein that is involved in the function of the nervous system; however its specific role is not well understood.

Can a syringomyelia disorder mimic peripheral neuropathy?

Peripheral neuropathy can also be mimicked by myelopathy, syringomyelia or dorsal column disorders, such as tabes dorsalis. Hysterical symptoms can sometimes mimic a neuropathy. FIGURE 1. Algorithm for evaluation of a patient with a peripheral neuropathy.

How to develop an algorithm for peripheral neuropathy?

An Algorithm for the Evaluation of Peripheral Neuropathy 1 Anatomy. The peripheral nerves include the cranial nerves (with the exception of the second), the spinal nerve roots, the dorsal root ganglia, the peripheral nerve trunks and their terminal branches, 2 Pathophysiology. 3 Diagnostic Approach. 4 History.

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