Where are foam cells located?

Foam cells are a type of macrophage that localize to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.

What process can involve the formation of foamy macrophage in arteries?

When inflow and esterification of cholesterol increase and/or its outflow decrease, the macrophages are ultimately transformed into lipid-laden foam cells, the prototypical cells in the atherosclerotic plaque.

Are foam cells cancerous?

Recent studies have also reported foam cells in cancer. Papillary renal cell carcinoma, a prevalent renal cell carcinoma, features a papillary growth pattern with focal aggregation of foam cells [116]. Foam cells can also be found in human esophageal xanthoma [117] and in non-small cell lung carcinoma [118].

Are foam cells inflammatory?

Foam cells are a rich source of proinflammatory mediators and there is strong evidence that support a central role for inflammation in all phases of the atherosclerotic process which includes the activation of numerous different cell types and chemoattractant agents such as proinflammatory cytokines, macrophages, and T …

How big are foamy histiocytes after surgery?

–aggregates of foamy histiocytes 1 –2 mm (post surgery –Billroth II –CMV infection (Lerut E e a Tijdschr Geneesk 2002; 58: 985) • Pigmented cells :

Which is nonneoplastic breast lesion has foamy histiocytes?

Nonneoplastic inflammatory breast lesion characterized by necrotic adipose tissue with foamy histiocytes, chronic inflammatory cells and multinucleated giant cells Due to postradiation vascular damage with subsequent ischemia, including external beam, mammosite, iridium implantation and intraoperative radiation

Where are the fatty streaks found in atherosclerosis?

Eventually, the foam cell will undergo apoptosis and die, but the lipid will accumulate in the intima. Fatty streaks are the first signs of atherosclerosis that are visible without magnification. They consist of lipid-containing foam cells in the arterial wall just beneath the endothelium.

What are the role of foam cells in atherosclerosis?

Macrophage foam cells play a critical role in the occurrence and development of atherosclerosis. The generation of these cells is associated with imbalance of cholesterol influx, esterification and efflux. CD36 and scavenger receptor class A (SR-A) are mainly responsible for uptake of lipoprotein-derived cholesterol by macrophages.