What if ristocetin cofactor is low?

If the VWF antigen test is normal or nearly normal and the VWF activity (Ristocetin Cofactor) is decreased, then the person may have Type 2 VWD. Further testing (e.g., VWF multimeric analysis) will be required to determine which subtype is present.

What is a ristocetin cofactor?

Ristocetin Cofactor – von Willebrand disease is the most common hereditary bleeding disorder. von Willebrand Factor is necessary for platelet adhesion to injured endothelium. Ristocetin cofactor is useful in assessing binding of von Willebrand Factor to platelet factor GP1b.

What causes low von Willebrand factor?

VWF can be low because there is a problem with how it is made and released from cells or may be related to blood type. Though there is less VWF (low), VWF works like it is supposed to. Low VWF isn’t always genetic (passed down from parent to child through information in the cells called the VWF gene)

What foods to avoid if you have hemophilia?

Food and supplements to avoid

• large glasses of juice.
• soft drinks, energy drinks, and sweetened tea.
• heavy gravies and sauces.
• butter, shortening, or lard.
• full-fat dairy products.
• candy.
• foods containing trans fats, including fried. foods and baked goods (pastries, pizza, pie, cookies, and crackers)

What is the normal range for von Willebrand factor?

In the general population, the mean level of plasma VWF is 100 IU per dL, with a normal reference range between 50 and 200 IU per dL.

Does hemophilia shorten life expectancy?

Many patients still die before adulthood due to inadequate treatment. With proper treatment, life expectancy is only about 10 years less than healthy men. Overall, the death rate for people with hemophilia is about twice that of the rate for healthy men. For severe hemophilia, the rate is four to six times higher.

When to test for ristocetin cofactor in von Willebrand?

In patients with mild von Willebrand disease, ristocetin cofactor activity may at times be in the low normal range. If the diagnosis is strongly suspected, testing should be repeated within weeks or months. Reference range is 50 – 200%. Specimen requirement is one light blue top (sodium citrate) tube of blood.

When to use von Willebrand factor VIII coagulant?

Using VWF antigen results along with the VWF activity (Ristocetin Cofactor) and factor VIII coagulant activity give the optimal combination for diagnosis and management. If the VWF antigen test is normal or nearly normal and the VWF activity (Ristocetin Cofactor) is decreased, then the person may have Type 2 VWD.

What is a von Willebrand factor ( vWF ) activity?

What It Is A von Willebrand factor (vWF) activity – ristocetin cofactor test lets doctors evaluate the functioning of the protein vWF, which helps blood to clot. A clot is a lump of blood that the body produces to prevent excessive bleeding by sealing leaks from blood vessels caused by wounds, cuts, scratches, or other conditions.

What is the function of the ristocetin cofactor?

Ristocetin Cofactor This test evaluates the function of von Willebrand factor by testing ristocetin-induced aggregation of normal platelets in the presence of the patient’s plasma. It measures the binding activity of vWF to platelet glycoprotein 1b.