What are CD133 cells?

CD133 (prominin-1) is a cell surface glycoprotein expressed on CSCs in several solid tumors such as glioma, lung, liver, and colorectal cancer and is responsible for a drug-resistant phenotype and poor prognosis (Dragu, Necula, Bleotu, Diaconu, & Chivu-Economescu, 2015).

What is CD44 a marker for?

CD44 is a compelling marker for cancer stem cells of many solid malignancies. In addition, interaction of HA and CD44 promotes EGFR-mediated pathways, consequently leading to tumor cell growth, tumor cell migration, and chemotherapy resistance in solid cancers.

What is cancer stem cell marker?

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface markers provide molecular targeted therapies for various cancers, using therapeutic antibodies specific for the CSC surface markers.

What stains Sox2?

Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. Indirect immunofluorescent staining of Sox2-overexpressing cells showed strong nuclear and diffuse cytoplasmic immunoreactivity for Sox2 in the antichicken Sox2 antibody-staining cells.

How is CD133 related to cancer stem cells?

The concept of the so-called cancer stem cell (CSC) holds that only a minority of cells within a tumor have the ability to generate a new tumor. Over the last decade, a large body of literature has implicated the protein CD133 as a marker of organ-specific adult stem cells and in some cancers as a bona fide CSC marker.

Where is CD133 found in the human colon?

CD133 is expressed in differentiated epithelium of normal human colon. ( A and B) Immunostaining with CD133 (AC133) antibody (red) demonstrates the luminal localization (indicated with the arrows) of CD133 in normal human colon. ( C and D) Coimmunofluorescence with CD133 (AC133) antibody (red) and EpCAM…

Where can I find jci-cd133 expression?

1 Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA. 2 Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA. 3 Sloan-Kettering Cancer Center, New York, New York, USA.