How long does it take for Zofran to kick in?

How quickly does Zofran (ondansetron) work? Zofran (ondansetron) should work pretty quickly. Many people report relief within about 30 minutes and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.

Why is Zofran every 8 hours?

For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose.

What is the onset of ondansetron?

A 4 mg intravenous infusion of ondansetron given over 5 minutes results in peak plasma concentrations of about 65 ng/ml. Following intramuscular administration of ondansetron, peak plasma concentrations of about 25 ng/ml are attained within 10 minutes of injection.

Why am I still nauseous after taking Zofran?

The mechanism of the drug involves blocking serotonin, which can cause vomiting. Doctors will look at your liver health and weight when deciding how much of the drug you should take. While Zofran can offer relief to some patients who can’t eat or struggle with chronic nausea, it can also create severe side effects.

What is the pH of Zofran injection solution?

ZOFRAN Injection is a clear, colorless, nonpyrogenic, sterile solution. The pH of the injection solution is 3.3 to 4.0. CLINICAL PHARMACOLOGY Pharmacodynamics: Ondansetron is a selective 5-HT 3 receptor antagonist. While ondansetron’s mechanism of action has not been fully characterized, it is not a dopamine-receptor antagonist.

How long does it take for Zofran to take effect?

Response and Effectiveness The peak effect of Zofran is reached within 1.5-2 hours. The onset of effect is faster with the orally disintegrating or liquid form.

Which is the active ingredient in Zofran injection?

The active ingredient in ZOFRAN Injection is ondansetron hydrochloride (HCl), the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT 3 receptor type. Chemically it is (±) 1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H­ carbazol-4-one, monohydrochloride, dihydrate.

What are the strengths of Zofran ODT tablets?

Zofran ODT orally disintegrating tablets are white, round, and plano-convex tablets available in the following strengths: 4 mg – debossed with “Z4” on one side. 8 mg – debossed with “Z8” on one side. ZOFRAN oral solution, 4 mg/5 mL, is a clear, colorless to light yellow liquid with a characteristic strawberry odor available in a 50-mL bottle.