What type of genome does HPV have?

Human papillomavirus (HPV) is a small, non-enveloped deoxyribonucleic acid (DNA) virus that infects skin or mucosal cells. The circular, double-stranded viral genome is approximately 8-kb in length.

Does HPV integrate into the genome?

HPV infection includes integration of the HPV genome into the host genome. This integration leads to the linearization of the HPV genome, usually somewhere the region of the E1 and E2 genes, but can also cause the partial or total deletion of these genes5,6.

What is HPV 18 detected?

The HPV test is a screening test for cervical cancer, but the test doesn’t tell you whether you have cancer. Instead, the test detects the presence of HPV , the virus that causes cervical cancer, in your system. Certain types of HPV — including types 16 and 18 — increase your cervical cancer risk.

How does HPV replicate its genome?

HPV infects dividing basal epithelial cells where its dsDNA episomal genome enters the nuclei. Upon basal cell division, an infected daughter cell begins the process of keratinocyte differentiation that triggers a tightly orchestrated pattern of viral gene expression to accomplish a productive infection.

What are the sublineages of HPV18 virus?

The 7 HPV18 genomes were assigned to the A3/A4 and A1 sublineages. Of the 11 HPV58 genomes, the most predominant variant sublineages were A2, followed by A1 and B2.

Where can I find the genetic sequence of HPV?

This Web site has two main branches. The first contains our four annual data books of papillomavirus information, called Human Papillomaviruses: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences.and the second contains papillomavirus genetic sequence data. The HPV Compendium

What’s the difference between HPV16 and HPV18?

However, there were no significant differences in the distribution of HPV16 A1–3 and A4 variants between CIN1-, CIN2/3, and cervical cancer groups. The 7 HPV18 genomes were assigned to the A3/A4 and A1 sublineages. Of the 11 HPV58 genomes, the most predominant variant sublineages were A2, followed by A1 and B2.

Are there any deletions in HPV 16 / 18?

The majority of HPV16/18 samples containing contiguous genomic deletions were found to harbor HPV integration. Some T-cell epitope sequences in HPV16 E6 and E7 showed considerable divergence from the prototype NC_001526, suggesting their importance in immunotherapy of HPV-associated carcinomas.