What is phentolamine mesylate used for?

Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor.

What type of drug is phentolamine mesylate?

Phentolamine Description Phentolamine Mesylate for Injection, USP is an antihypertensive, available in vials for intravenous and intramuscular administration.

How does phentolamine mesylate work?

Mechanism of Action Phentolamine mesylate, the active ingredient in OraVerse, produces an alpha-adrenergic block of relatively short duration resulting in vasodilatation when applied to vascular smooth muscle.

What is the mechanism of action of phentolamine?

Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen.

What is the side effect of phentolamine?

Phentolamine is available in an injectable form to be given by a healthcare professional directly into tissue of the mouth, a muscle, or a vein depending on the condition being treated or diagnosed. Common side effects of phentolamine include injection site pain, headache, and changes in heart rate.

What is another name for phentolamine?

Regitine, OraVerse (phentolamine) dosing, indications, interactions, adverse effects, and more.

How does phentolamine affect heart rate?

1 Intravenously administered phentolamine provoked immediate decreases in diastolic blood pressure but increases in heart rate and cardiac output.

How long does phentolamine last?

Peak serum concentrations of phentolamine are achieved within approximately 0.25 to 0.75 h after oral administration. The mean elimination half-life is approximately 2 h, and the duration of effect following administration is approximately 1–2 h.

Does phenylephrine make you sleepy?

Decongestants. Since the main symptom of a cold is congestion in your nose and/or chest, cold medicines usually contain a decongestant ingredient. Examples include phenylephrine and pseudoephedrine. These typically do not cause drowsiness and can make some people feel hyper or more alert.

How do you get phentolamine?

Phentolamine is available only with your doctor’s prescription. This product is available in the following dosage forms: Powder for Solution.

How long does phentolamine take to work?

This medicine usually begins to work in about 10 minutes. You should attempt intercourse within 2 hours after injecting the medicine. To reverse the effects of a soft-tissue anesthetic medicine, a dentist or other trained health professional will give you this medicine.

Is phentolamine used for erectile dysfunction?

In conclusion, this study shows that oral phentolamine is a well-tolerated and effective treatment for mild to moderate erectile dysfunction.