What does it mean for the gonads to be Bipotential?

A bipotential gonad is defined as an undifferentiated phase of gonadal development where the male (XY) and female (XX) undifferentiated gonads appear identical and they can either develop into testes or ovaries.

What does the cortex of the primordial gonad differentiate into?

Primordial germ cells have an inductive effect on development of the gonad into ovary or testis. In embryos with an XX sex chromosome complex, the cortex normally differentiates into an ovary and the medulla regresses.

What is are necessary for Bipotential gonad to become testes?

The gonad is bipotential, capable of forming either a testis or an ovary until about the sixth week of gestation. The initial formation of the bipotential gonad (from uncommitted urogenital ridge) requires the function of Wilm’s tumor (WT1) and steroidogenic factor (SF-1).

What are Bipotential cells?

Hepatoblasts are the cells that have migrated from the liver diverticulum into the septum transversum at ∼9.5 d of development in the mouse, and they are already determined along the hepatic epithelial cell lineage (Le Douarin, 1975; Houssaint, 1980; Zaret, 1996).

What is the function of the bipotential gonad?

The initial formation of the bipotential gonad (from uncommitted urogenital ridge) requires the function of Wilm’s tumor (WT1) and steroidogenic factor (SF-1). Both are transcription factors (see glossary) and key in both gonadal and kidney development. Fig. 14-3: Time course of differentiation of the bipotential gonad. 14-6

Is the insanity defense based on a theory?

An insanity defense is based on the theory that the majority of individuals can choose to follow the law or not. A few individuals cannot be held accountable because mental illness or defect deprives them of making a rational and voluntary choice.

How is insanity defined in the criminal law?

Using the Irresistible Impulse test, the law defines an insane defendant as unable to control their impulses leading to the commission of a criminal act.

What is the role of the gonad in sex determination?

Primary sex determination is the decision by which the bipotential embryonic gonad commits to either the testicular or ovarian fate. The developing gonad constitutes a unique paradigm for the study of lineage specification, cell fate commitment and the exploration of how distinct cell populations diverge from multipotent progenitors.