Can clopidogrel and dipyridamole be taken together?

Clopidogrel monotherapy is an alternate to aspirin plus dipyridamole, with a similar risk of bleeding [8, 41–44], while dipyridamole reduces the risk of recurrent stroke without excess bleeding [23]. No previous studies have evaluated the hemorrhagic complications of the clopidogrel–dipyridamole combination.

Can you take aspirin and clopidogrel together?

Do not take aspirin for pain relief (300mg tablets) or ibuprofen while you’re taking clopidogrel, unless a doctor has said it’s OK. They increase the chance of bleeding. You can take paracetamol together with clopidogrel.

Do aspirin and clopidogrel do the same thing?

Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin also is used to reduce fever, and to treat pain and inflammation in the body.

When do you take aspirin with clopidogrel?

Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke.

What is another name for dipyridamole?

Dipyridamole Brand names: Attia, Ofcram, Persantin, Persantin Retard, Trolactin.

What is the mechanism of action of clopidogrel?

The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP- mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible.

Which is better aspirin or clopidogrel?

The trial reported that long term administration of clopidogrel had better efficacy than aspirin for reducing a composite vascular events of ischemic stroke, acute myocardial infarction (AMI), or vascular death among all groups of patients with atherosclerotic vascular diseases.

Is dipyridamole irreversible?

Cilostazol, a 2-oxo-quinoline, is a potent, reversible type 3 phosphodiesterase inhibitor, targeting both platelets and vascular smooth muscle cells. Cilostazol also reduces cellular adenosine uptake.

What medications should not be taken with clopidogrel?

Clopidogrel may interact with other medications

• Diabetes drug. In most cases, repaglinide should not be taken with clopidogrel.
• Stomach acid drugs (proton pump inhibitors)
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Blood thinners.
• Drugs used to treat depression.
• Salicylates (aspirin)
• Opioids.

How is clopidogrel compared to dipyridamol alone?

4.1.12 The Assessment Group completed an indirect comparison that compared clopidogrel, modified- release dipyridamole plus aspirin, modified-release dipyridamole alone and aspirin using data from the four RCTs. Comparisons were made in a population of people with a history of ischaemic stroke or transient ischaemic attack.

Is it safe to take aspirin and dipyridamole together?

We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy.

What are the effects of aspirin and clopidogrel?

Effects of aspirin, clopidogrel and dipyridamole administered singly and in combination on platelet and leucocyte function in normal volunteers and patients with prior ischaemic stroke. Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in nformal volunteers and patients with prior ischaemic stroke.

Which is better for stroke prevention aspirin or dipyridamole?

Antiplatelet options for the prevention of recurrent stroke include aspirin (50 mg to 325 mg per day), the combination of low-dose aspirin and extended-release dipyridamole, and clopidogrel alone. Aspirin has been shown to reduce the risk of stroke recurrence by about 23% as compared with placebo.