What is small cell neuroendocrine prostate cancer?

Small cell prostate carcinoma (SCPC) is a rare form of extrapulmonary high-grade neuroendocrine carcinoma accounting for <0.5% to 1% of all prostate cancers (1). It is characterized by an aggressive clinical course and portends a poor prognosis.

How is small cell prostate cancer diagnosed?

The distribution of prostatic small cell carcinoma is similar to that of prostatic adenocarcinoma. Most patients have multifocal disease but also have a dominant nodule located in the peripheral zone. These tumors may be felt by digital rectal examination and can be diagnosed by needle core biopsy.

Is prostate cancer a neuroendocrine?

Clinical and genomic profiling data propose that neuroendocrine prostate cancers may originate de novo from a small population of neuroendocrine cells present in the prostate (2–4). However in the majority of cases these tumors diverge from a population of luminal-derived metastatic castrate-resistant adenocarcinoma.

Is neuroendocrine the same as small cell carcinoma?

Small cell lung cancer (SCLC) is the most common form of neuroendocrine lung cancer. A rare form of neuroendocrine lung cancer is called large cell neuroendocrine carcinoma. This cancer looks and acts like SCLC, except that the cancerous cells themselves are larger, and it is treated in much the same way as SCLC.

What is small cell endometrial cancer?

Small Cell Neuroendocrine Carcinoma of Uterus is a rare subtype of neuroendocrine endometrial cancer. They are usually high-grade tumors that arise from the body of the uterus. The cancer shows similar morphological features of other neuroendocrine tumors, such as of small cell carcinoma of lung.

What is the prognosis for neuroendocrine tumors?

What Is The Prognosis For Neuroendocrine Cancer . Neuroendocrine cancer prognosis – Overall, it is estimated that more than 12 000 people in the United States are annually diagnosed with neuroendocrine tumors. A 5-year survival rate tells you which percentage of people live at least 5 years after cancer detection.

What is a Grade 1 neuroendocrine tumour?

Grade 1 (also called low-grade or well-differentiated) neuroendocrine tumors have cells that look more like normal cells and are not multiplying quickly . Grade 2 (also called intermediate-grade or moderately differentiated) tumors have features in between those of low- and high-grade (see below) tumors.

Can prostate cancer be completely cured?

Early prostate cancer is often completely asymptomatic. By the time the disease becomes symptomatic it is usually beyond cure. Prostate cancer that is confined to the gland itself can be cured by radical surgery or radiotherapy, but the benefit of cure only becomes apparent after 10 years.