What is modified form of Skraup synthesis?

Quinolines may be obtained by the Skraup synthesis. This involves heating aniline or a substituted aniline with glycerol in the presence of sulphuric acid, ferrous sulphate and nitrobenzene. It involves dehydration of glycerol by means of sulphuric acid to give acrolein. …

Which oxidant is used in Skraup reaction?

nitrobenzene
The Skraup reaction is used to synthesize quinolines. [1, 2] In the typical Skraup reaction, aniline is heated with sulfuric acid, glyc- erol (HO-CH2-CH(OH)-CH2-OH) and an oxidizing agent such as nitrobenzene (Scheme 1).

Which of the following reaction is used for the synthesis of quinoline?

Quinolines may be obtained by the Skraup synthesis. This involves heating aniline or a substituted aniline with glycerol in the presence of sulphuric acid, ferrous sulphate and nitrobenzene. The reaction is complex. It involves dehydration of glycerol by means of sulphuric acid to give acrolein.

What kind of reaction is the Skraup reaction?

The synthesis of quinoline derivatives from primary aromatic amines, glycerol, and an oxidizing agent in concentrated sulfuric acid is generally known as the Skraup reaction. It has been reported that initial Skraup protocol usually gives a very low yield of quinolines.

What are the steps in Skraup’s chemical synthesis?

Skraup’s Synthesis. Step 1: Formation of acrolein by the action of H2SO4 on glycerine. Dehydration of glycerine results in the loss of two molecules of water ultimately resulting in the formation of acrolein. Step 2: Action of Acrolein on Aniline forming the addition product and intramolecular electrophilic addition followed by protonation,…

What does Skraup stand for in organic chemistry?

Skraup synthesis. [skrau̇p ′sin·thə·səs] (organic chemistry) A method for the preparation of commercial synthetic quinoline by heating aniline and glycerol in the presence of sulfuric acid and an oxidizing agent to form pyridine unsubstituted quinolines.

How is the Skraup method used for quinoline synthesis?

… The Skraup procedure [1] is a classical method for the synthesis of quinoline that involves use of a large amount of sulfuric acid at temperatures above 150 C, and the reaction is violent.