What is LMD 10%?

10% LMD (dextran 40) is an artificial colloid pharmacologically classified as a plasma volume expander; 5% Dextrose Injection is a fluid and nutrient replenisher; 0.9% Sodium Chloride Injection is a fluid and electrolyte replenisher.

What is dextran 40 used for?

LMD (dextran 40) is indicated for use in the adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma. It is not indicated as a replacement for whole blood or blood components if they are available.

What is low molecular weight dextran?

These polysaccharides, have the ability to alter blood-flow properties. The alterations vary with the molecular weight of the dextran. Low-molecular weight dextran has demonstrated its ability to decrease blood viscosity and reverse cell aggregation, producing an increase in blood flow and tissue perfusion.

What is the molecular weight of the dextran?

504.4
3.1Computed Properties

What type of fluid is dextran?

High-molecular weight dextran is a plasma volume expander made from natural sources of sugar (glucose). It works by restoring blood plasma lost through severe bleeding. Severe blood loss can decrease oxygen levels and can lead to organ failure, brain damage, coma, and possibly death.

What is LMD on agents of shield?

A Life Model Decoy (or LMD for short) is a S.H.I.E.L.D.-designed robot that duplicates all outward aspects of a living person. The owner can see through, speak through, and control everything the Life Model Decoy does.

Why is dextran used?

Dextran is a medication used in managing and treating various clinical conditions, including during hemorrhage, shock, surgical procedures, radiological imaging, antithrombotic administration, and ophthalmic relief of xerophthalmia.

Is dextran 40 a colloid?

Dextran is a synthetic colloid consisting of mixture of glucose polymers derived from the action of Leuconostoc mesenteroides on sucrose and is currently available in 10% dextran 40 (40 kDa) and 6% dextran 70 (70 kDa).

How is dextran formed?

Dextran is now produced from sucrose by certain lactic acid bacteria of the family lactobacillus. Species include Leuconostoc mesenteroides and Streptococcus mutans. The structure of dextran produced depends not only on the family and species of the bacterium but on the strain.

Is dextran a crystalloid?

We compared a new hyperoncotic priming solution containing dextran 40, which has an electrolyte composition that mimics extracellular fluid, with a standard crystalloid-based prime.

Is dextran 70 safe for eyes?

Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: eye pain, change in vision, continued eye redness/irritation. A very serious allergic reaction to this drug is rare.

Is dextran an anticoagulant?

Carboxymethyl dextran benzylamide sulfonate/sulfates (CMDBS) are synthetic polysaccharides with anticoagulant activity. The anticoagulant activity of CMDBS was due both to direct thrombin inhibition and to catalysis of thrombin inhibition by HCII.

Which is the correct formula for dextran 40 injection?

LMD (dextran 40) is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection. It is administered by intravenous infusion.

What is the osmolar concentration of dextran 40?

Total osmolar concentration is 255 mOsmol/liter (calc.); pH is 4.4 (3.0 to 7.0). Each 100 mL of 10% LMD (dextran 40) in 0.9% Sodium Chloride Injection contains 10 g dextran 40 and 0.9 g sodium chloride in water for injection.

How many dextrose hydrous are in 10% LMD?

More than 90% of the linkages are of the 1,6 alpha glucosidic, straight chain type. Each 100 mL of 10% LMD (dextran 40) in 5% Dextrose Injection contains 10 g dextran 40 and 5 g dextrose hydrous in water for injection. Total osmolar concentration is 255 mOsmol/liter (calc.); pH is 4.4 (3.0 to 7.0).

What makes dextran 40 a low viscosity drug?

Also described as low viscous or low viscosity dextran, dextran 40 is prepared by acid hydrolysis and differential fractionation of a crude macromolecular polysaccharide produced from the fermentation of sucrose by the bacterium, Leuconostoc mesenteroides (strain B-512).