How is opioid induced pruritis treated?

Systemic opioid–induced itching is usually treated with H1 blockers such as diphenhydramine. Numerous drugs are available for attempts to prevent or treat neuraxial opioid–induced itching. The treatment of itching induced by drugs other than opioids differs according to the drug involved and its mechanism of action.

How is pruritus from intrathecal morphine treated?

Conclusion: Ondansetron treats intrathecal morphine-induced pruritus after cesarean delivery, particularly in patients suffering from both nausea/vomiting and pruritus.

Can opioid cause itching?

A common side effect of opioids is intense itching — a problem for some patients who need the drugs for pain relief and for others fighting addiction.

Can Benadryl help with opioid itching?

Most studies conclude that opioid antagonists are the best treatment; however, they also decrease the analgesic effect. A recent study has compared Odansetron and diphenhydramine treatment for pruritus in women who received intrathecal opioids and found them equally effective.

Which is the best medicine for opioid induced pruritus?

Opioids are one of the best‐known medicines evoking pruritus. The pathogenesis of opioid‐induced pruritus is still not fully known, but two different mechanisms have been proposed: peripheral and central. Several treatment options have been tested for opioid‐induced pruritus, but none has been completely satisfactory.

What causes itching after neuraxial opioid use?

The itching or pruritus is a very annoying secondary effect that appears after the neuraxial administration (epidural or intrathecal) of opioid drugs. Sometimes, it can even be more unpleasant that the own pain in or by itself.

Is the scratching a side effect of opioids?

Learn more. Pruritus is an unpleasant sensation leading to scratching. It can be a feature of numerous skin or systemic diseases, and may also be a side‐effect of various drugs. Opioids are one of the best‐known medicines evoking pruritus.

How are opioids related to other adverse effects?

The mechanisms by which opioids cause these adverse effects are not always completely understood.