How do you use recombinant human erythropoietin injection?

Recombinant Human Erythropoietin Alfa helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy. It is given as a single injection under your skin.

What does recombinant human erythropoietin do for athletes?

Recombinant human erythropoietin (rHuEPO) has been used as a performance‐enhancing agent by athletes in a variety of sports. The resulting increase in hematocrit levels leads to increased blood viscosity and can affect blood flow, potentially increasing the athlete’s risk of developing health complications.

How is recombinant human erythropoietin produced?

rhEPO is produced with the use of cells transfected with either the human EPO gene or EPO cDNA (the coding sequence of the gene) linked to an expression vector (‘recombinant DNA’), which are integrated into the genome of the host cell and stably expressed over time.

What is the therapeutic use of recombinant erythropoietin?

Patients with chronic renal failure have subnormal endogenous erythropoietin production. Clinical studies have shown that RHuEPO therapy corrects the anaemia of chronic renal failure, avoids blood transfusions and improves quality of life.

Where is EPO produced?

Erythropoietin (EPO) is a peptide hormone that is produced by the kidneys in response to hypoxia sensed by pericellular cells positioned in the vasculature of the renal matrix.175.

What does erythropoietin, recombinant mean?

Recombinant erythropoietin is a man-made version of natural erythropoietin. It is produced by cloning the gene for erythropoietin. Recombinant erythropoietin drugs are known as erythropoietin-stimulating agents (ESAs). These drugs are given by injection (shot) and work by stimulating the production of more red blood cells.

What is human body organ produce erythropoietin?

Erythropoietin (EPO) is a hormone produced by the kidney that promotes the formation of red blood cells by the bone marrow. The kidney cells that make erythropoietin are sensitive to low oxygen levels in the blood that travels through the kidney. These cells make and release erythropoietin when the oxygen level is too low.

What is the function of erythropoietin?

The main function of erythropoietin is to stimulate the bone marrow for the production of more red blood cells. The increase in red blood cells increases the capacity of oxygen transport in the blood. Among the main functions of erythropoietin are: Promotes the development of red blood cells.