When was sodium valproate first used?

Valproate (variously labelled worldwide as Epilim, Depacon, Depakene, Depakote, Orlept, Episenta, Orfiril, and Convulex) is one of the world’s most highly prescribed treatments for epilepsy. It was first discovered to be an effective treatment for epilepsy, by accident, in 1963 by a group of French scientists.

How was valproate discovered?

In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol-induced convulsions in laboratory rats.

When was valproic acid discovered?

The anticonvulsant properties of N-dipropylacetic acid (valproic acid) were discovered in 1967 by Meunier and Carraz. It very soon became widely used in epilepsy, generally in the form of sodium valproate.

Who discovered valproic acid?

Valproic acid (VPA; valproate; di-n-propylacetic acid, DPA; 2-propylpentanoic acid, or 2-propylvaleric acid) was first synthesized in 1882, by Burton [1], but there was no known clinical use until its anticonvulsant activity was fortuitously discovered by Eymard.

When was valproic acid first used in medicine?

Valproic acid is a branched short-chain fatty acid (SCFA) made from valeric acid. Valproate was first made in 1881 and came into medical use in 1962. Valproate is included in the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.

What kind of Medicine is valproate used for?

Valproate (VPA), and its valproic acid, sodium valproate, and valproate semisodium forms, are medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.

What do you need to know about valproate poisoning?

Few historical features are specifically suggestive of valproate (valproic acid [VPA]) toxicity. As in most poisonings, a clinical history of the ingestion, including the amount and exact time of ingestion, is helpful. Adequate documentation of previous medical and psychiatric problems is essential.

What kind of effects does valproate have on the brain?

Valproate can cause altered visual evoked potentials and brainstem evoked potentials [ 48 ].