What does a toxic neutrophil look like?

In many infections or toxic stimulations, neutrophils respond with large dark blue intracytoplasmic azurophilic granules . These toxic granules may be unmasked in metamyelocytes, bands, and segmented neutrophils in such instances. Their presence indicates active phagocytosis with an increase in lysosomal activity.

What does toxic granulation of neutrophils mean?

Although normal, mature neutrophils do contain some primary granules, the granules are difficult to identify by light microscopy because they lose their dark blue colour as the cells mature. Toxic granulation thus represents abnormal maturation of neutrophils.

How do you identify toxic granulation?

Toxic granulation is manifested by the presence of large granules in the cytoplasm of segmented and band neutrophils in the peripheral blood. The color of these granules can range from dark purplish blue to an almost red appearance.

What does toxic granulation mean on CBC?

Toxic granulations are darker-coloured granules that can be seen under a microscope in neutrophils, the most abundant class of white blood cells. These granules are often larger and more abundant than normal granules. Their presence is non-specific and usually signals a bacterial infection or inflammation.

What does toxic granulation mean?

Toxic granulation refers to dark coarse granules found in granulocytes , particularly neutrophils, in patients with inflammatory conditions.

What is toxic granulation on CBC?

‘Toxic granulation’ is the term used to describe an increase in staining density and possibly the number of granules that occurs regularly with bacterial infection and often with other causes of inflammation (Fig. 5-75).

What is toxic granulation present?

Toxic Granulation. Toxic granulation is manifested by the presence of large granules in the cytoplasm of segmented and band neutrophils in the peripheral blood. The color of these granules can range from dark purplish blue to an almost red appearance.