Why is gemcitabine given before cisplatin?

The recommendation to administer gemcitabine prior to cisplatin is based on results of phase 1 studies in adults with solid tumors, which indicated that this administration schedule may increase the generation of platinum-DNA adducts (potentially increasing efficacy) and reduce neutropenia.

How many cycles of gemcitabine and cisplatin can you have?

Gemcitabine + cisplatin is repeated every 21 or 28 days. This is known as one Cycle. Each cycle may be repeated up to four times if the disease is not metastatic. If the disease is metastatic, then each cycle may be repeated up to 6 times.

Can gemcitabine cure lung cancer?

Over the last decade, gemcitabine, a pyrimidine nucleoside antimetabolite, has been one of the most effective agents for patients with advanced non-small cell lung cancer.

How effective is cisplatin for lung cancer?

Current evidence suggests that it may be the most effective single drug for the treatment of NSCLC patients. The overall response rate as a single agent is 21%, though responses are higher in previously untreated patients given high doses. Cisplatin combinations are the most effective therapy for advanced NSCLC.

How effective is gemcitabine and cisplatin?

One patient (9%) had complete remission of disease and 6 (55%) achieved a partial response to chemotherapy with an overall response rate of 64%. Median time to progression was 28 weeks and median overall survival was 42 weeks. Toxicity was easily manageable, and no treatment-related deaths occurred.

How many cycles of cisplatin can you have?

You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months. You have gemcitabine as a drip into your bloodstream over 30 minutes. You have cisplatin as a drip into your bloodstream over 1 to 4 hours.

Is cisplatin a strong chemo?

Cisplatin is a potent chemotherapeutic drug that has shown efficacy for the treatment of many malignancies including head and neck, ovarian, sarcomas, lymphoma, and prostate cancer.

Does chemo work on stage 4 lung cancer?

In stage IV lung cancer, chemotherapy is typically the main treatment. In stage IV patients, radiation is used only for palliation of symptoms. The chemotherapy treatment plan for lung cancer often consists of a combination of drugs.

How many chemo sessions are needed for lung cancer?

You get chemo in cycles of 3 to 4 weeks. Between cycles, you can rest and recover. You may take your drug only once a week or over a few days of each cycle. If your cancer is advanced, you may need four to six cycles of treatment.

What is the longest someone has lived with stage 4 lung cancer?

“It is possible shorter survival in other studies may be associated with use of non-pemetrexed based chemotherapies.” “At this point, 6.8 years is one of the longest median survivals ever reported for a NSCLC subpopulation stage IV disease,” Pacheco concluded.

Can stage 4 lung cancer go into remission?

There is currently no cure for stage 4 lung cancer. However, certain treatments can alleviate the symptoms and prolong a person’s life. The best approach to treatment depends partly on the type of lung cancer. There are two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).

How bad is cisplatin?

Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.

How often do you infuse cisplatin with gemcitabine?

Protocol: Cisplatin/Gemcitabine Indications: Lung Cancer (non-small cell) – Adjuvant, Neoadjuvant Schedule: Drug Dose iv/infusion/oral q Cisplatin 50mg/m2 1L N. Saline/2hrs Day 1, 2 Gemcitabine 1250mg/m2200mls N. Saline/30mins Days 1 & 8 Cycle frequency: Every three weeks Total number of cycles: 4

How are carboplatin and gemcitabine used in cancer treatment?

Department of Medical Oncology Chemotherapy Protocols 3rdEdition 1 Protocol: Carboplatin/Gemcitabine Indications: Lung Cancer (non-small cell) – Advanced Schedule: Drug Dose iv/infusion/oral q Carboplatin AUC 5 500mls 5% dex/1hr Day 1 Gemcitabine 1200mg/m2200mls N. Saline/30mins Days 1 & 8

How often should I take cisplatin for lung cancer?

Cisplatin 100 mg/m 2 IV on day 1 plus etoposide 100 mg/m 2 IV on days 1-3 every 28 d [ 1, 2, 3] or Cisplatin 80 mg/m 2 IV on days 1, 22, 43, and 64 plus vinblastine 4 mg/m 2 IV on days 1, 8, 15, 22, and 29; then every 2 wk after day 43 until completion of cisplatin every 21 d [ 1, 2, 3] or

How often should I take carboplatin for lung cancer?

Protocol: Carboplatin/Gemcitabine Indications: Lung Cancer (non-small cell) – Advanced Schedule: Drug Dose iv/infusion/oral q Carboplatin AUC 5 500mls 5% dex/1hr Day 1 Gemcitabine 1200mg/m2200mls N. Saline/30mins Days 1 & 8 Cycle frequency: Every three weeks Total number of cycles: 4 Dose modifications: Discuss with Consultant