Why is Dubin Johnson asymptomatic?

This condition is associated with a defect in the ability of hepatocytes to secrete conjugated bilirubin into the bile, and is similar to Rotor syndrome. It is usually asymptomatic, but may be diagnosed in early infancy based on laboratory tests. No treatment is usually needed….

What causes Dubin-Johnson syndrome?

Dubin-Johnson syndrome is caused by changes in a gene known as ABCC2. The ABCC2 gene provides instructions for making a protein that transports certain substances out of cells so they can be released (excreted) from the body.

How is Dubin-Johnson syndrome treated?

Dubin-Johnson syndrome is a benign disorder and does not require any specific therapy, although patients should be warned that pregnancy, oral contraceptive use, and intercurrent illness can exacerbate the associated jaundice.

What happens to coproporphyrins in Dubin-Johnson syndrome?

Coproporphyrins. An increase in the urinary excretion of coproporphyrin I and a decrease in the excretion of coproporphyrin III are observed in Dubin-Johnson syndrome. [16] This results in total urinary coproporphyrin excretion (I+III) that is nearly normal when compared with unaffected individuals.

What is the ratio of coproporphyrin III to 1?

Unaffected subjects have a coproporphyrin III to coproporphyrin I ratio around 3–4:1. In patients with Dubin–Johnson syndrome, this ratio is inverted, with coproporphyrin I being 3–4 times higher than coproporphyrin III.

Is it possible to diagnose Dubin-Johnson syndrome?

When the history and physical examination findings are consistent, the urinary coproporphyrin excretion pattern supports the diagnosis of Dubin-Johnson syndrome. However, the overlap of results in carriers with those in controls350 makes identification of heterozygotes difficult. Robert J. Desnick,

How long does bromsulphthalein clearance take for Dubin Johnson syndrome?

In case of Dubin–Johnson syndrome, clearance of bromsulphthalein will be within 90 minutes, while in case of Rotor syndrome, the clearance is slow, i.e., it takes more than 90 minutes for clearance. Dubin–Johnson syndrome is a benign condition and no treatment is required.