What is the significance of Stomatocytes?

Stomatocytes have been noted in diverse acquired conditions, including neoplasms, cardiovascular and hepatobiliary disease, alcoholism, and therapy with drugs, some of which are known to be stomatocytogenic in vitro.

What does Ovalocytes 2+ mean?

Abnormal results mean the size, shape, color, or coating of the RBCs is not normal. Some abnormalities may be graded on a 4-point scale: 1+ means one quarter of cells are affected. 2+ means one half of cells are affected. 3+ means three quarters of cells are affected.

What is Stomatocytes blood test?

Stomatocytes are red blood cells that, under a microscope, look like “kissing lips” or “coffee beans” rather than a biconcave disc with a clear centre.

What causes Ovalocytes blood?

Iron deficiency anemia, a common type of anemia that is seen when there is insufficient iron in the body, contains elliptocytes (ovalocytes). Megaloblastic anemia caused by a deficiency of either folate or vitamin B-12 contains dacrocytes (teardrop cells), elliptocytes.

What do you need to know about the Stomatocyte?

Stomatocyte 1 Red Blood Cell Membrane Disorders. 2 Other Hereditary Red Blood Cell Disorders. 3 Blood cell morphology in health and disease. 4 Disorders of Red Blood Cells—Anemias. 5 Blood Cell Morphology in Health and Disease. 6 Red Cell Membrane and Enzyme Defects.

What is the percentage of stomatocytes on peripheral blood smear?

Acquired Stomatocytosis Stomatocytes have been noted in diverse acquired conditions, including neoplasms, cardiovascular and hepatobiliary disease, alcoholism, and therapy with drugs, some of which are known to be stomatocytogenic in vitro. In some of these conditions, the percentage of stomatocytes on the peripheral blood smear can approach 100%.

Is the Stomatocyte gene hereditary or acquired?

Stomatocytosis is either hereditary or acquired. Hereditary stomatocytosis is an autosomal dominant genetic disorder leading to the increased permeability of the red cells to sodium. The increased permeability to sodium in some studies was associated with a deficiency of the erythrocyte membrane protein stomatin (band 7.2b).

How does hereditary stomatocytosis affect the red blood cell?

Hereditary stomatocytosis. Hereditary stomatocytosis describes a number of inherited autosomal dominant human conditions which affect the red blood cell, in which the membrane or outer coating of the cell ‘leaks’ sodium and potassium ions.