What is the role of ceruloplasmin?

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism….Ceruloplasmin.

Is ceruloplasmin an antioxidant?

Ceruloplasmin (Cp) is a copper-containing ferroxidase that functions as an antioxidant in part by oxidizing toxic ferrous iron to nontoxic ferric iron.

Where is ceruloplasmin found?

Ceruloplasmin is a protein that is made in the liver. It stores and carries copper from the liver into the bloodstream and to the parts of your body that need it. Copper is a mineral that is found in several foods, including nuts, chocolate, mushrooms, shellfish, and liver.

What is the function of the serum ceruloplasmin?

Ceruloplasmin Function. Ceruloplasmin is a multi-copper serum ferroxidase that needs copper to oxidize ferrous iron (Fe 2+) into ferric iron (Fe 3+) to enable cellular iron transport.

Where does ceruloplasmin transport ferrius iron in the cell?

Ferrous iron is taken at the cell surface, it is oxidized by ceruloplasmin and it is then transported by transferrin, which is an extracellular iron transporter that can carry iron only in its ferric form (Fe 3+ ).

How is ceruloplasmin related to the transport of copper?

Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. The rest is accounted for by macroglobulins. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe 2+ (ferrous iron) into Fe 3+ (ferric iron), therefore assisting in its transport in…

What happens when Fe2 + is oxidized by ceruloplasmin?

Evidence suggests that ceruloplasmin is involved in oxidizing Fe2+ when iron status is low 1. Once oxidized, Fe3+ binds to transferrin and is transported to a tissue cell that contains a transferrin receptor. Transferrin binds to the transferrin receptor and is endocytosed, as shown below 2.