What is the product of acetanilide and P-nitroacetanilide?

When acetanilide is treated with nitrating mixture that is a mixture of nitric acid and sulfuric acid p-nitroacetanilide is formed. Along with p-nitroacetanilide, o-nitroacetanilide is also formed as a minor product. Since o-nitroacetanilide is very much soluble in alcohol it is very easy to isolate p-nitroacetanilide through crystallization.

How to make H2SO4 with P-nitroacetanilide?

Place 30 g of p-nitroacetanilide and 150 ml of 70% H2SO4 (prepared by adding 100 ml conc. acid to 75 ml water carefully) in a round-bottomed flask. Reflux the mixture for 20-30 min. and pour the hot solution into 1000 ml of cold water. Neutralize with 10% NaOH, cool and filter the yellow crystalline product on a Buchner funnel.

How is P-nitroacetanilide washed with cold water?

The separated p-nitroacetanilide is washed with cold water in order to remove excess of acid. It is crystallized from ethyl alcohol. Dry the crystals in the folds of filter paper and weigh them to know the yield.

How are large crystals of P-nitroacetanilide prepared?

Large crystals of p-nitroacetanilide is obtained. Filter the crystals through filter paper. The separated p-nitroacetanilide is washed with cold water in order to remove excess of acid. It is crystallized from ethyl alcohol.

What happens when Acetanilide is treated with sulphuric acid?

When acetanilide is treated with nitrating mixture that is a mixture of nitric acid and sulphuric acid p-nitroacetanilide is formed. Along with p-nitroacetanilide, o-nitroacetanilide is also formed as a minor product. Since o-nitroacetanilide is very much soluble in alcohol it is very easy to isolate p-nitroacetanilide through crystallization.

How is benzene used in the nitration of acetanilide?

Basically the whole mechanism undergoes as below; (Benzene is shown here instead of acetanilide ) To prevent dinitration of the acetanilide, the nitrating mixture of concentratred nitric acid and sulfuric acids were added in small portions to the acetanilide solution, so that the concentration of the nitrating agent is kept at minimum.

How to make acetanilide from glacial acetic acid?

Add dry acetanilide (25 g) to glacial acetic acid (25 ml) in a beaker and then introduce concentrated sulphuric acid (50 ml) slowly with constant stirring to obtain clear solution. Place the beaker in a freezing mixture of ice and salt to cool the solution below 5 oC.