What is the mechanism of action of paclitaxel?

Mechanism of action Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division. Unlike other tubulin-targeting drugs, such as colchicine, that inhibit microtubule assembly, paclitaxel stabilizes the microtubule polymer and protects it from disassembly.

How does paclitaxel work against cancer cells?

Clinically relevant concentrations of paclitaxel kill tumor cells by inducing multipolar divisions. Cells entering mitosis in the presence of concentrations of paclitaxel equivalent to those in human breast tumors form abnormal spindles that contain additional spindle poles.

How does paclitaxel stop cell division?

Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res.

How does the drug paclitaxel inhibit the growth of cancer?

Unlike other tubulin-binding anticancer drugs, which prevent the assembly of tubulin into microtubules, paclitaxel promotes the assembly of tubulin into microtubules and prevents the dissociation of microtubules, blocking cell cycle progression, preventing mitosis, and inhibiting the growth of cancer cells [2].

What are the mechanisms of action of paclitaxel?

Taxol (paclitaxel): mechanisms of action Paclitaxel, an antitumor drug that is demonstrating encouraging activity in human malignancies, is likely to play a major role in cancer chemotherapy. Paclitaxel has an unusual chemical structure–it is a complex diterpene having a taxane ring with a four-membered oxetane ring and an ester side chai …

How are paclitaxel and olaparib resistance mediated?

Active efflux of paclitaxel, olaparib, doxorubicin and rucaparib was confirmed in drug-resistant cells and in ABCB1-expressing bacterial membranes. Conclusions: We describe a common ABCB1-mediated mechanism of paclitaxel and olaparib resistance in ovarian cancer cells.

Is the paclitaxel sold by LC laboratories for human use?

NOTE: THE PACLITAXEL SOLD BY LC LABORATORIES FOR RESEARCH IS NOT ABRAXANE® or TAXOL®, AND IS NOT FOR HUMAN USE. Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.

How does ABCB1 affect resistance to paclitaxel?

Resistance correlated with increased ABCB1 expression and was reversible following treatment with the ABCB1 inhibitors verapamil and elacridar. Active efflux of paclitaxel, olaparib, doxorubicin and rucaparib was confirmed in drug-resistant cells and in ABCB1-expressing bacterial membranes.