What is the karyotype for Klinefelter syndrome?

Klinefelter Syndrome (47, XXY) is a chromosomal variation in males in which one extra X chromosome is present, resulting in a 47,XXY karyotype. The extra X chromosome typically affects physical, neurodevelopmental, behavioral, and neurocognitive functioning.

How long can a person live with Klinefelter’s syndrome?

According to research, Klinefelter syndrome can shorten your life expectancy up to two years.

Is Klinefelter syndrome caused by Nondisjunction?

However, because of nondisjunction, an egg cell or a sperm cell can also end up with an extra copy of the X chromosome. If an egg cell with an extra X chromosome (XX) is fertilized by a sperm cell with one Y chromosome, the resulting child will have Klinefelter syndrome.

Does Klinefelter syndrome affect intelligence?

Most males with the 47,XXY karyotype have normal intelligence. Intellectual disability occurs in males with Klinefelter syndrome variants, who have a higher number of X chromosomes. About 70% of patients have minor developmental and learning disabilities.

How does Klinefelter syndrome affect a person’s life?

But the condition can bring challenges later in life. For example, guys with Klinefelter syndrome may be more likely to get some types of cancer and other diseases, like type 2 diabetes and osteoporosis, a condition where the bones become weaker later in life.

What happens to a person with Klinefelter syndrome?

Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue.

What is it like to live with Klinefelter syndrome?

They may tend to be quiet, shy, and more reserved or sensitive than other guys. Some boys with Klinefelter syndrome are less interested in sports or physical activities. Since high-school life often revolves around schoolwork and sports, guys with Klinefelter may feel like they don’t fit in or lack self-confidence.

How bad is Klinefelter syndrome?

Klinefelter syndrome may increase the risk of: Anxiety and depression. Social, emotional and behavioral problems, such as low self-esteem, emotional immaturity and impulsiveness. Infertility and problems with sexual function.

Are there any support groups for Klinefelter syndrome?

The American Association for Klinefelter Syndrome Information and Support (AAKSIS) is a national volunteer association with the mission of education, support, research, and understanding of 47 XXY and its variants, collectively known as Klinefelter syndrome.

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