What is the drug of choice for nocturnal enuresis?

PHARMACOLOGIC TREATMENT Desmopressin (DDAVP) and imipramine (Tofranil) are the primary drugs used in the treatment of nocturnal enuresis. Pharmacologic treatment is not recommended for children under six years of age.

What does Monosymptomatic enuresis mean?

Monosymptomatic enuresis – Monosymptomatic enuresis is defined as enuresis in children without any other lower urinary tract symptoms and without a history of bladder dysfunction [1]. Monosymptomatic nocturnal enuresis usually is divided into primary and secondary forms.

How does desmopressin work for enuresis?

Desmopressin works by reducing the amount of urine produced in the body at night by the kidneys. This means that the bladder then fills with less urine during the night. Desmopressin is usually taken at bedtime.

What is Monosymptomatic nocturnal enuresis?

● Primary monosymptomatic nocturnal enuresis (ie, bedwetting) is defined by discrete episodes of urinary incontinence during sleep in children ≥5 years of age who have never achieved a satisfactory period of nighttime dryness, have no other lower urinary tract symptoms, and have no history of bladder dysfunction.

Can nocturnal enuresis be cured?

Sometimes doctors treat enuresis with medicine. But no medicine has been proved to cure bedwetting permanently, and the problem usually returns when the medicine is stopped. Doctors sometimes prescribe a manmade form of ADH to decrease urine buildup during the night.

What is the best treatment for enuresis?

Desmopressin acetate. Desmopressin acetate is the preferred medication for treating children with enuresis. A Cochrane review of 47 randomized trials concluded that desmopressin therapy reduces bedwetting; children treated with desmopressin had an average of 1.3 fewer wet nights per week.

Is enuresis a mental disorder?

The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) characterizes enuresis as a disorder when there is a persistent loss of bladder control after age 5 years.

What happens if you take too much desmopressin?

If you take too much desmopressin or drink too much fluid while taking it, it can cause your body to retain too much water. This can result in: headaches. dizziness.

How do I get my 10 year old to stop peeing the bed at night?

To combat bed-wetting, doctors suggest:

1. Shift times for drinking.
2. Schedule bathroom breaks.
3. Be encouraging.
4. Eliminate bladder irritants.
5. Avoid thirst overload.
6. Consider if constipation is a factor.
7. Don’t wake children up to urinate.
8. An earlier bedtime.

Can bedwetting be cured?

Nearly all bedwetting problems can be cured with single or combination therapy. Some people do, however; they will need long-term drug therapy.

When to use desmopressin acetate nasal spray in adults?

Desmopressin Acetate Nasal Spray is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus in adults and pediatric patients 4 years of age and older. Use in patients requiring doses less than 10 mcg or doses that are not multiples of 10 mcg [see Dosage Forms and Strengths (3) ].

Is there a nasal spray for nocturnal enuresis?

Nasal formulations of desmopressin are no longer indicated for primary nocturnal enuresis.

How is desmopressin used to treat nocturnal enuresis?

Desmopressin is a synthetic analogue of vasopressin, and is indicated for treatment of primary nocturnal enuresis (PNE); nocturia associated with multiple sclerosis when other treatments have failed; and diagnosis and treatment of vasopressin-sensitive cranial diabetes insipidus;

Can you get hyponatraemia from desmopressin nasal spray?

There is some evidence from post-marketing data for the occurrence of severe hyponatraemia in association with the nasal spray formulation of desmopressin, when it is used in the treatment of cranial diabetes insipidus.