What is mouse ICR?

The ICR mouse is a strain of albino mice originating in SWISS and selected by Dr. Hauschka to create a fertile mouse line. Because mice of this strain have been sent to various places from the Institute of Cancer Research in the USA, the strain was named ICR after the initial letters of the institute.

What is mouse haplotype?

Mouse MHC antigen is also called H-2 antigen. Its gene is located on mouse chromosome 17. They are involved in presentation of processed peptide antigens to CD4+ cells. MHC molecules are highly polymorphic. Laboratory mice are inbred so that each strain is homo- zygous and has a unique MHC haplotype.

What is H2 haplotype?

The word haplotype describes the haploid complement of linked Mhc loci inherited together on a single chromosome, but we define it operationally and the limits are variable. Just how variable is evident from the range of lengths of the differential segment in H2 congenic strains (Klein et al. 1982; Vincek et al.

What are the Mhc haplotypes of laboratory mice?

MHC molecules are highly polymorphic. Laboratory mice are inbred so that each strain is homo- zygous and has a unique MHC haplotype. The MHC haplotype in these strains is designated by a small letter (a, b, d, k, q, s, etc.). For example, MHC haplotype antigens of BALB/c mice are H-2K d , H-2D , H- 2L d , I-A , and I-E . Table:

What kind of haplotype does ICR / Haj have?

Inbred ICR/HaJ, which we imported from Dr. Rosemary Elliott at the Roswell Park Cancer Institute and is derived from ICR, matches this fecundity. ICR/HaJ shares the diabetogenic H2g7 MHC haplotype with NOD, which is also ICR-derived. Unlike NOD, however, ICR/HaJ is insulitis-and diabetes-free.

Who is the inventor of the ICR mouse?

The ICR outbred model was developed by Dr. T. S. Hauschka of Fox Chase Cancer Center in 1948. Dr. Hauschka left Fox Chase a portion of his colony. Taconic received breeder stock from Fox Chase in 1993. The mice were derived by hysterectomy into IBU colonies and are maintained by Poiley rotational bred mice.

How old is the ICR strain in mice?

A quantity of twenty mice (ten males and ten females) was submitted for testing, strain identified as Line ICR (IcrTac:ICR), age 7 weeks.