What is cutaneous focal Mucinosis?

Cutaneous focal mucinosis (CFM) is a localized form of cutaneous dermal mucinosis clinically presenting as an asymptomatic skin-colored papule or nodule that occurs anywhere on the body or in the oral cavity. The etiopathogenesis of CFM is unclear, but it is thought to represent a reactive and not a neoplastic lesion.

What is follicular Mucinosis?

Follicular mucinosis is an uncommon inflammatory disorder that characteristically presents as follicular papules and/or indurated plaques. The face, neck, and scalp are the most frequently affected sites, although lesions may occur on any site of the body.

How is cutaneous mucinosis treated?

Plaquelike cutaneous mucinosis treatments are mostly based on case reports. Antimalarial drugs and topical or systemic corticosteroids are the most frequently used.

What causes mucinosis?

Mucinosis is believed to be the result of a genetic defect, most probably relating to the metabolism of hyaluronic acid. Mucinosis is most often seen on the neck, shoulder area, hocks, forelimbs, and around the anus. It can be concurrent, or even caused by, hypothyroidism.

How is Scleromyxedema diagnosed?

The diagnosis of scleromyxedema is based upon the following clinico-pathologic criteria: 1) Generalized papular and sclerodermoid eruption; 2) Microscopic triad including mucin deposition, fibrosis and fibroblast proliferation; 3) Monoclonal gammopathy; absence of a thyroid disorder.

What is dermal mucin?

Mucin (hyaluronic acid complex) is a protein normally found as part of the dermal connective tissues and it is produced by mast cells and fibroblasts. As hyaluronic acid holds water, in disease states where mucin production is increased, the dermal connective tissue becomes swollen and is described as myxedematous.

What does follicular mucinosis look like?

It is characterised by bald patches of skin in which hair follicles are prominent. Mucins look like stringy clear or whitish goo mainly composed of hyaluronic acid, a normal component of the ground substance surrounding collagen in the dermis. Several other forms of mucinosis are described and classified.

Is follicular mucinosis contagious?

There is no clear known cause for MF or FMF. Cutaneous lymphomas are not contagious and cannot be passed from one person to another, and they generally are not inherited. What Does Folliculotropic Mycosis Fungoides Look Like?

What is mucin in the skin?

Mucins are high-molecular weight glycoproteins typically found in normal skin in small amounts. There are several reports regarding different types of cutaneous mucinosis. In this report, we discuss mucins in dermatopathology as a diagnostic clue of some well-known entities and some less frequent cutaneous diseases.

Is scleromyxedema an autoimmune disease?

Scleromyxedema (SM) is a rare disorder which initially presents with waxy skin stiffness and maculopapular lesions. It also has non-dermatologic manifestations, such as serum paraproteinemia and myopathies, and is sometimes associated with other autoimmune disorders.

What can mimic scleroderma?

However, similar features of hard and thick skin can be seen in other conditions which are often referred to as “scleroderma mimics”. These mimics include eosinophilic fasciitis, nephrogenic systemic fibrosis, scleromyxedema, and scleredema among others.

What causes increased dermal mucin?

What is the definition of cutaneous focal mucinosis?

Cutaneous focal mucinosis (CFM) was originally described as an asymptomatic solitary lesion characterized by abundant focal Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma‐like cutaneous mucinous lesions – Kuo – 2017 – The Journal of Dermatology – Wiley Online Library Skip to Article Content

What is the treatment for oral focal mucinosis?

Because the color is typically similar to the adjacent mucosa, the lesion often mimics an ordinary fibroma. Treatment consists of excisional biopsy, and the lesion should not recur. Oral focal mucinosis may be a response to inflammation.

Why does mucinosis have a myxomatous appearance?

Because this tissue is relatively acellular and contains abundant ground substance, it has a myxomatous (mucinous) appearance microscopically. It is believed to represent the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst.

Which is the most common location of mucinosis?

Oral focal mucinosis occurs most often in young adults and shows a 2 : 1 female-to-male predilection. The most common location is the gingiva, which accounts for two-thirds to three-quarters of all cases. The lesion appears as a sessile or pedunculated, painless nodule that can measure from several millimeters to 2 cm in diameter.