Popular tips

What is congenital insensitivity to pain with anhidrosis?

What is congenital insensitivity to pain with anhidrosis?

Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV.

What makes CIPA and Anhidrosis an extremely serious condition?

There are individuals who are insensitive to pain. This can be the result of inherited disorder known as CIPA (congenital insensitivity to pain with anhidrosis). This is an extremely rare disorder which may also cause a person to produce very little sweat or none at all and makes them incapable of feeling temperature.

What can you infer about people with CIPA?

Congenital insensitivity to pain and anhydrosis (CIPA) is a rare hereditary disease that causes affected individuals to be unable to feel pain and unable to sweat (anhydrosis). It is also called hereditary sensory and autonomic neuropathy type IV (HSAN IV).

Is CIPA a mental illness?

Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder of the nervous system which prevents the feeling of pain or temperature, and prevents a person from sweating. Cognitive disorders are commonly coincident.

Can CIPA patients feel?

They can feel pressure, but not pain, so they are likely to injure or mutilate themselves without meaning to. They might know they slammed their hand in the door, it just doesn’t hurt. This inability to feel physical pain does not extend to emotional pain — people with CIPA feel emotional pain just like anyone else.

Can congenital insensitivity to pain be treated?

Inheritance is autosomal recessive . There is still no cure for CIPA. Treatment is aimed at controlling body temperature, preventing self-injury, and treating orthopedic problems, as soon as possible. It is very important to control the body temperature during surgery.

How is CIPA treated?

There is still no cure for CIPA. Treatment is aimed at controlling body temperature, preventing self-injury, and treating orthopedic problems, as soon as possible. It is very important to control the body temperature during surgery.

Can you live with CIPA?

CIPA is extremely dangerous, and in most cases the patient doesn’t live over age of 25. Although some of them can live a fairly normal life, they must constantly check for cuts, bruises, self-mutilations, and other possible unfelt injuries.

Does CIPA have a cure?

Can CIPA patients smell?

Actually, they wouldn’t know because people with congenital insensitivity to pain can’t smell anything. Researchers have discovered that these individuals who have a rare genetic condition rendering their lives pain-free also don’t have a sense of smell.

Why is congenital insensitivity to pain bad?

People with CIPA cannot feel pain [1]. Pain-sensing nerves in these patients are not properly connected in parts of brain that receive the pain messages. CIPA is extremely dangerous, and in most cases the patient doesn’t live over age of 25.

Congenital insensitivity to pain with anhidrosis (CIPA), also known as hereditary sensory and autonomic neuropathy type IV (HSAN IV), is characterized by insensitivity to pain, anhidrosis (the inability to sweat), and intellectual disability.

What does congenital insensitivity to pain ( CIPA ) mean?

Excerpted from the GeneReview: Congenital Insensitivity to Pain with Anhidrosis. Congenital insensitivity to pain with anhidrosis (CIPA), also known as hereditary sensory and autonomic neuropathy type IV (HSAN IV), is characterized by insensitivity to pain, anhidrosis (the inability to sweat), and intellectual disability.

What does NTRK1 congenital insensitivity to pain mean?

NTRK1 congenital insensitivity to pain with anhidrosis (NTRK1-CIPA) is characterized by insensitivity to pain, anhidrosis (the inability to sweat), and intellectual disability.

How does congenital insensitivity to pain affect life expectancy?

Over time, this lack of pain awareness can lead to an accumulation of injuries and health issues that may affect life expectancy. Congenital insensitivity to pain is caused by mutations in the SCN9A gene and, in rare cases, is caused by mutations in the PMRD12 gene. It is inherited in an autosomal recessive pattern.

https://www.youtube.com/watch?v=n6iOUW523BE