What does CK5 6 positive mean?

Cytokeratin 5/6 is a positive marker for malignant pleural mesothelioma, found in more than three-fourths of cases. It is also found in certain types of lung cancers and breast cancers.

What does CK5 6 negative mean?

In this study, we adopted the widely accepted definition in which CK5/6- and/or EGFR-positive breast cancers are classified as BLBC while CK5/6- and EGFR-negative breast cancers are defined as non-basal-like breast cancer (NBLBC).

What is CK7 positive mean?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

Are there antibodies that target cytokeratin 5 and 6?

From Wikipedia, the free encyclopedia Cytokeratin 5/6 antibodies are antibodies that target both cytokeratin 5 and cytokeratin 6. These are used in immunohistochemistry, often called CK 5/6 staining, including the following applications: Identifying basal cells or myoepithelial cells in the breast and prostate.

What kind of cancer does cytokeratin 5 / 6 react with?

It has also been shown to react with cytokeratin 6, weakly with cytokeratin 4, and does not react with cytokeratins 1, 7, 8, 10, 13, 14, 18 and 19. CK5/6 has been shown to express in the vast majority of squamous cell carcinoma, basal cell carcinomas, thymomas, salivary gland tumors, and mesothelioma.

Can a pan-CK marker detect cytokeratin 5 / 6?

Accessed June 6th, 2021. CK5 also detected by antibodies against high molecular weight cytokeratins (such as 34βE12, also known as K903) and pan-CK markers (such as CK AE1/AE3) Stains basal cells of prostate and basal / myoepithelial cells of breast and is used to rule out invasion

How is cytokeratin used to diagnose breast cancer?

Stains basal cells of prostate and basal / myoepithelial cells of breast and is used to rule out invasion Useful for detecting benign breast proliferations (mosaic-like pattern) versus ductal carcinoma in situ (DCIS) (negative or rarely diffusely positive) ( Pathology 2009;41:68 )