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What chemo drugs are highly emetogenic?

What chemo drugs are highly emetogenic?

Some highly emetogenic agents and chemotherapy regimens include:

  • ABVD.
  • AC.
  • BEP.
  • Cisplatin.
  • Carmustine (>250 mg/m2)
  • CBV.
  • Cyclophosphamide (>1500 mg/m2)
  • Dacarbazine.

Is BEP highly emetogenic?

Cisplatin is classified as a highly emetic risk agent (6), and a high incidence of chemotherapy-induced nausea and vomiting (CINV) is reported in BEP (7). The administration of 5-HT3 receptor antagonist in addition to dexamethasone and NK1 receptor antagonist is required during BEP for the prevention of CINV (6).

Which anticancer drug has high emetogenic potential?

Table 2

Emetogenic potential Cytotoxic drug
High Cisplatin
Cyclophosphamide
Dacarbazine
Mechloretamine

What’s the difference between carboplatin and etoposide?

Administration Carboplatin is administered in 500mL 5% glucose over 60 minutes. Etoposide is administered in sodium chloride 0.9% (concentration dependent) and infused over 2 hours. Consider using etoposide phosphate (Etopophos) due to high dose and therefore high volume of fluid required. Pre-medication Antiemetics as per local guidelines

What is the emetogenic potential of antineoplastic agents?

EMETOGENIC POTENTIAL OF ANTINEOPLASTIC AGENTS EMETOGENIC POTENTIAL OF ANTINEOPLASTIC AGENTS High Risk (>90% frequency without antiemetics) † AC combination: Doxorubicin (Adriamycin) or Epirubicin (Ellence) Cyclophosphamide (Cytoxan, Neosar) † Altretamine (HMM, Hexalen) † Carmustine (BCNU, BiCNU) 250mg/m 2

How long does it take to infuse etoposide with carboplatin?

Administration Carboplatin is administered in 500mL 5% glucose over 60 minutes. Etoposide is administered in sodium chloride 0.9% (concentration dependent) and infused over 2 hours. Consider using etoposide phosphate (Etopophos) due to high dose and therefore high volume of fluid required.

Which is the best definition of emetogenicity?

Emetogenicity: the propensity of an agent to cause nausea, vomiting or retching. High emetic potential: greater than 90% frequency of emesis in the absence of effective prophylaxis. Moderate emetic potential: 30 to 90% frequency of emesis in the absence of effective prophylaxis.