What are the steps in the synthesis of benzocaine?

1 SYNTHESIS OF BENZOCAINE 2 the resonance窶都tabilized intermediate I, followed by (2) the nucleophilic attack of the alcohol. The subsequent transfer of the proton (3), loss of water (4), and loss of proton (5) then give the ・］al observed products. The reverse reaction to yield the carboxylic acid and alocohol follows the same steps in the opposite

How to make benzocaine from para-aminobenzoic acid?

In step 1 common reduction of aromatic para-nitrobenzoic acid by tin and hydrochloric acid to para-aminobenzoic acid and in step 2 esterification of para-aminobenzoic acid by sulphuric acid and ethanol to benzocaine occurring called Fischer esterification.1 Aim: To prepare Benzocaine from p- nitrobenzoic acid.

How to make a local anesthetic benzocaine at home?

The mixture was cooled in an ice bath and 2.5 ml (0.045 mole) of concentrated sulfuric acid were slowly added. A large amount of precipitate formed, but slowly dissolved when the mixture was re・Ｖxed. A re・Ｖx condenser was attached and the mixture was heated under re・Ｖx for 2 hours. During this time, the mixture was swirled

Can a benzocaine be extracted from sodium bisulfate?

Under these conditions, much of the nonionic benzocaine formed in the experiment should remain dis- solved, and some ionic sodium bisulfate and unreacted sodium p–aminobenzoate may precipitate. Extraction of ths mixture with ether permits the separation of the benzocaine from the ionic compounds.

How is benzocaine produced in a reflux reaction?

The intention of the experiment was to synthesise benzocaine, an ester, from 4-aminobenzoic acid, a carboxylic acid, by Fischer Esterification. The mechanism in figure 1 was to combined 4-aminobenzoic acid and ethanol in a reflux reaction with the addition of sulphuric acid as a catalyst to produce the product.