What are Category D drugs in pregnancy?

Category D: Drugs in this class may be used in pregnancy if the benefits to the mother outweigh the risk to the fetus (i.e. a life threatening situation or a serious disease for which safer medication cannot be used or are not efficacious). Examples of medications in this class are phenytoin and valproic acid.

Is Namenda safe during pregnancy?

There are no adequate and well-controlled studies of memantine in pregnant women. NAMENDA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

What drug category is not safe for pregnancy?

Some of the over-the-counter medicines that increase the chances of birth defects are: Bismuth subsalicylate (such as Pepto-Bismol). Phenylephrine or pseudoephedrine, which are decongestants. Avoid medicines with these ingredients during the first trimester.

Is it safe to take memantine while pregnant?

memantine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether memantine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

What are the effects of memantine on a newborn?

-The effects in the nursing infant are unknown. Animal studies revealed oral administration of this drug during late gestation and lactation were associated with increased post-implantation loss and transiently reduced neonatal bodyweight at estimated systemic exposures 4-fold that of anticipated clinical exposure at the recommended dose.

What are the side effects of memantine and donepezil?

Animal studies with donepezil showed an increase in stillbirths and reduced offspring survival at oral doses up to 7 times the MRHD. Other doses of memantine and donepezil examined in animal studies, including doses up to 21 and 15 times the MRHD, did not show any teratogenic effects.

Which is the highest dose of memantine for no effect?

The higher no -effect dose for adverse developmental effects (6 mg/kg) is 3 times the maximum recommended human daily dose (MRHD) of memantine hydrochloride (20 mg) on a body surface area (mg/m 2) basis.