Is transposition of the great arteries hereditary?

Background Transposition of the great arteries (TGA) is considered to be associated only rarely with genetic syndromes and to have a low risk of precurrence among relatives of affected patients.

Can TGA be detected before birth?

TGA is sometimes diagnosed by fetal ultrasound before the baby is born. First trimester screening for chromosomal abnormalities is a good screening tool to identify patients who might be at an increased risk for cardiac defects.

Is Cctga genetic?

In conclusion, CCTGA is not always sporadic in families. The pattern of inheritance, the presence of consanguinity among parents and the recurrence of situs inversus could suggest, in some families, an autosomal recessive mechanism with similarities with that occurring in some pedigrees with heterotaxia.

Can transposition of the great arteries be misdiagnosed?

Although it’s possible your baby’s transposition of the great arteries may be diagnosed before birth, it can be difficult to diagnose. Prenatal tests for transposition of the great arteries aren’t usually done unless your doctor suspects your baby may have congenital heart disease.

How rare is transposition of the great arteries?

Occurrence. The Centers for Disease Control and Prevention (CDC) estimates that about 1,153 babies are born with TGA each year in the United States. This means that every 1 in 3,413 babies born in the US is affected by this defect.

What causes baby TGA?

TGA is a congenital heart defect. This means it’s a problem with the heart’s structure that your child was born with. The exact cause is unknown, but most cases seem to occur by chance.

How common is TGA in newborns?

The Centers for Disease Control and Prevention (CDC) estimates that about 1,153 babies are born with TGA each year in the United States. This means that every 1 in 3,413 babies born in the US is affected by this defect.

How rare is CCTGA?

Congenitally corrected transposition of the great arteries (CCTGA) is a rare heart defect. Only 0.5 to 1 percent of all people with heart defects have CCTGA. This means there are about 5,000 to 10,000 people in the United States with this condition.

What is transposition of the great arteries ( TGA )?

What is transposition of the great arteries? Transposition of the great arteries (TGA) is a type of heart defect that your baby is born with (congenital). In this condition, the two arteries that carry blood from the heart to the lungs and body aren’t connected as they should be. They are reversed (transposed).

Are there prenatal tests for transposition of the great arteries?

Prenatal tests for transposition of the great arteries aren’t usually done unless your doctor suspects your baby may have congenital heart disease.

Can a chest X-ray show transposition of the great arteries?

Although a chest X-ray doesn’t provide a definitive diagnosis of transposition of the great arteries, it does allow the doctor to see your baby’s heart size and the position of the aorta and pulmonary artery.

What kind of mutations are involved in TGA?

Changes ( mutations) in specific genes including the GDF1, CFC1 and MED13L (also called THRAP2) genes have been implicated in only a small minority of TGA cases. [2] [3] Making a diagnosis for a genetic or rare disease can often be challenging.