Is there an antibody test for dengue?

What is the test? The dengue MAC-ELISA is used for the qualitative detection of dengue virus IgM antibodies. The MAC-ELISA is based on capturing human IgM antibodies on a microtiter plate using anti-human-IgM antibody followed by the addition of dengue virus antigens.

How long do dengue antibodies last?

IgM antibodies become detectable 3 to 7 days following infection and may remain detectable for up to 6 months or longer following disease resolution.

When does dengue IgG become positive?

Anti-dengue virus IgG starts rising during 5–7 days after primary infection and even earlier in secondary infections (9, 11, 12) and the highest IgG titers appear during the 3rd week of a primary infection.

What is IgG IgM and NS1?

The NS1 detection rate is inversely proportional, whereas the IgM detection rate is directly proportional to the presence of IgG antibodies. The sensitivity and specificity in diagnosing acute dengue infection in the SD Duo NS1/IgM were 88.65% and 98.75%, respectively. The assay is sensitive and highly specific.

How are antibody tests used to diagnose dengue?

Antibody tests—these tests are primarily used to help diagnose a current or recent infection. They detect two different classes of antibodies produced by the body in response to a dengue fever infection, IgG and IgM.

What’s the range for dengue IgG and IgM?

Reference ranges: Dengue Fever Antibody (IgG) <0.80 Dengue Fever Antibody (IgM) <0.90 Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that you became infected with dengue virus within recent weeks.

When do dengue antibodies come positive for NS1?

Dengue Fever Antibodies (IgG, IgM) and NS1 Antigen Panel – NS1 antigen detection can serve as an effective bridge between dengue RNA detection (usually negative by day 5) and dengue IgM detection (may not be positive until day 6) for identifying acute dengue virus infection.

How is MAC-ELISA used to diagnose dengue?

The MAC-ELISA is based on capturing human IgM antibodies on a microtiter plate using anti-human-IgM antibody followed by the addition of dengue virus antigens. The antigens used for this assay are derived from the envelope proteins of the four dengue virus serotypes (DENV-1-4). How should it be used and at what time during infection?