How is hereditary fructose intolerance inherited?

Hereditary fructose intolerance is inherited, which means it can be passed down through families. If both parents carry a nonworking copy of the aldolase B gene, each of their children has a 25% (1 in 4) chance of being affected.

What gene causes hereditary fructose intolerance?

Mutations in the ALDOB gene cause hereditary fructose intolerance. The ALDOB gene provides instructions for making the aldolase B enzyme. This enzyme is found primarily in the liver and is involved in the breakdown (metabolism) of fructose so this sugar can be used as energy.

How can you tell if fructose intolerance is hereditary?

A diagnosis of HFI can be definitively confirmed by either of two tests: an enzyme assay, requiring a liver biopsy, to determine the level of aldolase activity or a fructose tolerance test in which the patient’s response to intravenous fructose feeding is carefully monitored.

Why do you vomit in hereditary fructose intolerance?

Fructose and sorbitol Hereditary fructose intolerance is an autosomal recessive disorder with reduced activity of aldolase B in the liver, kidney, and small intestine. Ingestion of only a few grams of fructose, sorbitol, or sucrose causes abdominal pain and vomiting [10].

Is hereditary fructose intolerance fatal?

HFI is a benign condition when treated, but it is life-threatening and potentially fatal if left untreated.

Can you fix fructose intolerance?

No treatment can cure hereditary fructose intolerance. Instead, a person should avoid consuming fructose. As a fructose-free diet requires a person to avoid all fruits and numerous other foods, they may need support to eat a balanced, healthful diet and avoid nutritional deficiencies.

What not to eat if you are fructose intolerant?

People who have fructose intolerance should limit high-fructose foods, such as juices, apples, grapes, watermelon, asparagus, peas and zucchini. Some lower fructose foods — such as bananas, blueberries, strawberries, carrots, avocados, green beans and lettuce — may be tolerated in limited quantities with meals.

How do you treat fructose intolerance?

Can you suddenly become fructose intolerance?

Hereditary fructose intolerance is a rare autosomal recessive disorder and, while most people are not born with it, its occurrence later in life is very common.

Is there a pill for fructose intolerance?

Lutomerase is a supplement that contains the enzyme xylose isomerase. This enzyme helps your body to completely digest the fructose in food. It turns the fructose in food into glucose, and makes sure that people with fructose malabsorption don’t develop any symptoms when they consume a product containing fructose.

Does fructose intolerance go away?

People with fructose malabsorption should keep a food log and follow a low fructose diet. Reducing fructose intake usually eases symptoms within about 2–6 weeks . After symptoms improve, a person can gradually reintroduce foods to see how much fructose they can tolerate.

How do I know if I have fructose intolerance?

Fructose intolerance symptoms include diarrhea or loose stools, abdominal pain, and gas after consuming a specific dose of fructose. These symptoms develop due to the fructose entering the large intestine where they may wreak havoc.

What foods are low in fructose?

Some lower fructose foods — such as bananas, blueberries, strawberries, carrots, avocados, green beans and lettuce — may be tolerated in limited quantities with meals. Read product labels carefully and avoid foods containing:

Are there any fruits I can eat if I have fructose intolerance?

People who have fructose intolerance should limit high-fructose foods, such as juices, apples, grapes, watermelon, asparagus, peas and zucchini. Some lower fructose foods – such as bananas, blueberries, strawberries, carrots, avocados, green beans and lettuce – may be tolerated in limited quantities with meals.

What are the signs of fructose intolerance?

While these symptoms are uncomfortable, they usually aren’t very serious. Symptoms of fructose intolerance can be more serious, including jaundice, or yellow skin, irritability, problems eating foods containing sucrose or fructose, excessive sleepiness, convulsions and vomiting.