How is FHH treated?

As FHH is usually asymptomatic, treatment is not necessary. The hypercalcemia seen in FHH does not respond to diuretics or bisphosphonates. For those with constantly elevated serum calcium concentrations >14mg/dL or in those with NSHPT or relapsing pancreatitis, a total parathyroidectomy can be beneficial.

What is FHH calcium?

Familial hypocalciuric hypercalcemia (FHH) is an inherited disorder that causes abnormally high levels of calcium in the blood (hypercalcemia) and low to moderate levels of calcium in urine (hypocalciuric). People with FHH usually do not have any symptoms and are often diagnosed by chance during routine bloodwork.

Why is urinary calcium low in FHH?

Pathogenesis. Most cases of FHH are associated with loss of function mutations in the calcium-sensing receptor (CaSR) gene, expressed in parathyroid and kidney tissue. These mutations decrease the receptor’s sensitivity to calcium, resulting in reduced receptor stimulation at normal serum calcium levels.

Is high calcium reversible?

If a person has lost bone mass or developed kidney stones due to excess blood calcium, those conditions can be treated. In most cases, osteoporosis caused by hypercalcemia is reversible after surgical cure of primary hyperparathyroidism.

Why are calcium levels high in PHPT and FHH?

Patients with pHPT and FHH both typically have elevated blood calcium levels and parathyroid hormone levels (PTH) that are not normal for the corresponding calcium levels (either high or inappropriately at the higher end of normal). This is a problem because only a select few patients with FHH will benefit from having parathyroid surgery.

How to reduce calcium levels in the body?

Hypercalcemia Symptoms 1 Hydrate. The first and perhaps most important step is to hydrate, hydrate, hydrate. 2 Eat Your Grains. 3 Reduce Phosphate. 4 Reduce Vitamin D Intake. 5 Chaste Tree. 6 Get Your Normal Amount of Calcium. 7 Lifestyle Changes to Reduce High Calcium Levels.

What’s the difference between FHH and hypocalciuric?

Thus, FHH is a very rare disease that runs in families which is associated with a higher than normal amount of calcium in the blood and a lower than normal amount of calcium in the urine.

How are calcium levels measured in urine for FHH?

The horizontal axis shows the amount of calcium in the urine of these 10,000 patients (always measured over a 24 hour period). The first thing that you will notice is that the 10,000 dots are completely random; they flow consistently from very low urine calcium levels to very high urine calcium levels.