How do you synthesize aspirin?
How do you synthesize aspirin?
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.
What is the chemical equation for the synthesis of aspirin?
The reaction, using molecular formulas is C7H6O3 + C4H6O3 –> C9H8O4 + C2H4O2. The relevant molecular weights are 180 grams per mole for aspirin, and 138 grams per mole for salicylic acid. An excess of acetic anhydride is used in this preparation.
How did Felix Hoffmann synthesis aspirin?
On 10 August 1897 Hoffmann synthesized acetylsalicylic acid (ASA) while working at Bayer under Arthur Eichengrün. By combining salicylic acid with acetic acid, he succeeded in creating ASA in a chemically pure and stable form.
What’s the generic name for aspirin?
Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain1,2 or inflammation….Other names.
| Generic name | Brand names |
|---|---|
| Aspirin | Aspro Clear®, Disprin® |
| Aspirin and codeine | Aspalgin®, Codral Cold & Flu Original® |
What is another name for aspirin?
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and Tylenol is an analgesic (pain reliever) and antipyretic (fever reducer). Brand names for aspirin include Bayer Aspirin, Ecotrin, and Bufferin.
What happens during the synthesis of aspirin?
To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, phosphoric acid will be used as the catalyst. The excess acetic acid will be quenched with the addition of water.
Where was aspirin found?
The aspirin we know came into being in the late 1890s in the form of acetylsalicylic acid when chemist Felix Hoffmann at Bayer in Germany used it to alleviate his father’s rheumatism, a timeline from Bayer says. Beginning in 1899, Bayer distributed a powder with this ingredient to physicians to give to patients.
Who really invented aspirin?
Felix Hoffmann
Aspirin/Inventors
In 1897, Felix Hoffman, a German chemist working for the Bayer company, was able to modify salicylic acid to create acetylsalicylic acid, which was named aspirin (Fig. 1).
Why is aspirin important?
Aspirin has been shown to be helpful when used daily to lower the risk of heart attack, clot-related strokes and other blood flow problems in patients who have cardiovascular disease or who have already had a heart attack or stroke. Many medical professionals prescribe aspirin for these uses.
How is the synthesis of aspirin done in the lab?
Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Salicylic acid (1.00 g + 0.005 g) and acetic anhydride (2.0 mL + 0.05 mL) were added to each of four test tubes. Sodium acetate (0.20 g) was added to one test tube.
How can aspirin be made from acetic acid?
Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst. The phenol group on the salicylic acid forms an ester with the carboxyl
Who was the first person to invent aspirin?
Felix Hoffmann, a German chemist, produced a stable form of acetylsalicylic acid, more commonly known as aspirin; in 1897. Aspirin is a derivative of salicylic acid that is a mild, nonnarcotic analgesic useful in the relief of headache and muscle and joint aches.
How is the theoretical yield of aspirin determined?
Prolonged contact with acid catalyst in the presence of water can lead to regeneration of salicylic acid starting material and reduce acetylsalicylic acid yield. The theoretical yield of 5.22 g acetylsalicylic acid was stoichiometrically determined using the starting mass of salicylic acid (4.0 g) because it was the limiting reactant.