Does grapefruit juice interfere with amlodipine?
Does grapefruit juice interfere with amlodipine?
Do not eat or drink lots of grapefruit or grapefruit juice while you’re taking this medicine. Grapefruit can increase the concentration of amlodipine in your body and worsen side effects.
How much amlodipine is in a grapefruit?
Calcium Channel Blockers
| DrugReference . | Grapefruit juice . | Compound . |
|---|---|---|
| Amlodipine39 | 250 mL | 5 mg, single-dose |
| AUC ↑ 16% | ||
| Diltiazem50,53 | 250 mL | 120 mg IR*, single-dose |
| AUC ↑ 20% ± 25% |
Why can’t you eat grapefruit with high blood pressure medication?
Calcium channel blockers They’re used as part of the treatment of conditions such as high blood pressure (hypertension) and coronary heart disease. Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood.
Can you drink orange juice with Norvasc?
aliskiren food GENERALLY AVOID: Coadministration with orange, apple, or grapefruit juice may significantly decrease the oral bioavailability and renin-inhibiting effect of aliskiren.
What medicines are affected by grapefruit juice?
Such classes include some sedatives, antianxiety agents, calcium channel blockers, certain statins (for high cholesterol), and antidepressants. Drugs that have been found to have the most marked interaction with grapefruit juice are as follows: felodipine, nitrendipine, nisoldipine, and saquinavir.
Should you avoid grapefruit juice?
Grapefruit is a healthy and delicious snack and juice, but it is best to avoid grapefruit and its juice if drug interactions are possible. Plus, there are hundreds of grapefruit interactions, and new ones are discovered often, including newly FDA-approved medications.
Can grapefruit juice interact with medications and drugs?
Examples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin , simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin ( Biaxin ), and loratadine (Claritin).
Is grapefruit juice bad for medicine?
Which Drugs are Most Dangerous to Take with Grapefruit Juice? Some cancer drugs, antibiotics, or heart medications may lead to an abnormal heart rhythm when combined with grapefruit. Muscle and kidney damage can be a serious side effect with statins used for lowering cholesterol. Some immunosuppressants used after organ transplants have been reported to cause kidney damage.