Can lorcaserin cause serotonin syndrome?

Because serotonin agonists such as lorcaserin can cause serotonin syndrome, the manufacturer recommends that patients taking other serotonergic drugs such as antidepressants avoid coadministration of lorcaserin.

What are the side effects of lorcaserin?

Lorcaserin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• constipation.
• dry mouth.
• excessive tiredness.
• pain in the back or muscles.
• headache.
• dizziness.
• difficulty falling asleep or staying asleep.
• anxiety.

Why is lorcaserin a controlled substance?

Side effects On 7 May 2013, the US Drug Enforcement Administration classified lorcaserin as a Schedule IV drug under the Controlled Substances Act. There has been concern that lorcaserin can cause cardiac valvulopathy based upon the reports of subjects taking the drug in Phase 2 trials.

What is the mechanism of action for lorcaserin?

MECHANISM OF ACTION The medication stimulates 5-HT2C receptors on the pro-opiomelanocortin (POMC) neurons in the arcuate nucleus; this causes the release of alpha-melanocortin-stimulating hormone (alpha-MSH), which acts on melanocortin-4 receptors in the paraventricular nucleus to suppress appetite.

How does contrave make you feel?

Nearly 1 in 4 people in the clinical trials stopped taking the prescription weight loss pill because they couldn’t tolerate the common side effects, including nausea, headache, and vomiting. Contrave can also cause increased blood pressure, anxiety, and insomnia. Other side effects include constipation and dizziness.

Can Belviq get you high?

In clinical trials of at least 1-year duration in obese patients, euphoria was observed in 0.17% of patients taking BELVIQ and 0.03% taking placebo.

What medications help with weight loss?

Four weight-loss drugs have been approved by the U.S. Food and Drug Administration for long-term use:

• Bupropion-naltrexone (Contrave)
• Liraglutide (Saxenda)
• Orlistat (Xenical)
• Phentermine-topiramate (Qsymia)

What is the best dietary approach to losing weight?

Many diets can help you lose weight. Some of the most well-researched diets and eating plans include intermittent fasting, plant-based diets, low-carb diets, low-fat diets, the paleo diet, the Mediterranean diet, WW (Weight Watchers), and the DASH diet.

Is Lorcaserin a stimulant?

Lorcaserin is a 5-HT2C receptor agonist that is approved by the Food and Drug Administration for the treatment of obesity (Belviq®) and is currently being considered as a treatment for stimulant abuse.

What kind of receptor does Lorcaserin bind to?

Lorcaserin is a small molecule that binds to one of the serotonin receptors, 5-HT2C receptor. 229 Serotonin is also known as 5-hydroxytryptamine (5-HT). Lorcaserin’s structure is shown below. Note the unusual seven-membered ring.

How many mg of lorcaserin can you take in one day?

Lorcaserin (10mg tablet twice daily) was approved in 2012 and a slow release preparation ( BELVIQ XR, 20 mg once daily) was approved in July and launched in October 2016. 27 Lorcaserin reduces food intake, possibly via suppressing appetite and increasing satiety, but the exact mechanism of action is unknown.

Which is better for weight loss Lorcaserin or fenfluramine?

Lorcaserin (Belviq) works as a serotonin 3C receptor agonist (whereas fenfluramine primarily acted as a 2B agonist) to increase food-specific receptors affecting satiety and satisfaction. A year-long study reported a weight loss of 7.3 kg with lorcaserin compared to the control group who lost 3.7 kg.

What happens to mood when serotonin levels are low?

For example, a 2007 study found that reduced levels of serotonin in the brain caused depression and other mood changes in women. Male participants, however, became more impulsive and didn’t report any mood changes.