Can hereditary multiple Exostoses be cured?

Surgery is used to remove the most symptomatic osteochondromas but because of their large number, many are left in place, causing life-long problems and increasing the probability of malignant transformation. There is no other treatment to prevent or reduce osteochondromas formation at present.

How rare is multiple hereditary Exostoses?

The incidence of hereditary multiple osteochondromas is estimated to be 1 in 50,000 individuals. This condition occurs more frequently in some isolated populations: the incidence is approximately 1 in 1,000 in the Chamorro population of Guam and 1 in 77 in the Ojibway Indian population of Manitoba, Canada.

How common is MHE?

MHE is relatively rare with an estimated prevalence in Caucasians of 1 per 50,000 individuals (2), as an incidence in the western population of 1,5% (3).

Is MHE rare?

MHE affects roughly 1 in 50,000 people. Most individuals with MHE have a parent who also has this condition, however approximately 10% of individuals with MHE have this condition as a result of a spontaneous mutation and are thus the first person in their family to be affected.

What do you need to know about Multiple Hereditary Exostoses?

Multiple Hereditary Exostoses. Multiple Hereditary Exostoses (MHE) is a rare bone disease that is characterized by growths of multiple osteochondromas—benign cartilage-capped bone tumors that grow outward from the growth plates of long bones. Osteochondromas can be associated with a reduction in skeletal growth, leading to short stature…

What kind of bone growth is caused by multiple exostosis?

The gene for hereditary multiple exostosis produces a protein that affects bone growth and development, causing bony growths called exostoses. The exostoses are categorized in two ways: sessile or pedunculated. Sessile exostoses are permanently attached or fixed and broad, while pedunculated exostoses are connected by a narrow stem.

What are the two types of multiple exostoses?

Two conditions in which multiple exostoses occur are metachondromatosis (156250) and the Langer-Giedion syndrome (LGS; 150230); the latter condition is also known as trichorhinophalangeal syndrome type II.

How are pedunculated and sessile multiple exostoses alike?

The exostoses are categorized in two ways: sessile or pedunculated. Sessile exostoses are permanently attached or fixed and broad, while pedunculated exostoses are connected by a narrow stem. Hereditary multiple exostosis is usually diagnosed around age 3 or 4, when the first exostosis occurs.