Which virus is responsible for vesicular stomatitis?

Rhabdovirus. Rhabdovirus, any of a group of viruses constituting the family Rhabdoviridae, responsible for rabies and vesicular stomatitis of cattle and horses.

Is vesicular stomatitis a virus?

Vesicular stomatitis is a viral disease which primarily affects horses, cattle, and swine. The agent that causes vesicular stomatitis, VSV, has a wide host range and can occasionally infect sheep and goats.

What is vesicular stomatitis virus glycoprotein?

The glycoproteins (G proteins) of vesicular stomatitis virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane fusion. The reversibility of their fusogenic conformational transitions differentiates them from many other low-pH-induced viral fusion proteins.

Is there a vaccine for vesicular stomatitis?

Therefore, effective vaccines against H5N1 viruses are needed to counter the potential threat of a global pandemic. We have previously developed a fast-acting and efficacious vaccine against Ebola virus (EBOV) using the vesicular stomatitis virus (VSV) platform.

What causes vesicular stomatitis virus?

Vesicular Disease in Humans Humans can contract vesicular stomatitis by coming into contact with lesions, saliva, or nasal secretions from infected animals. In people, the disease causes an acute influenza- like illness with symptoms such as fever, muscle aches, headache, and malaise.

Where does vesicular stomatitis come from?

It is caused by a virus and is found in the United States, Mexico, Central America and parts of South America. The vesicular stomatitis virus (VSV) causes blister-like sores on the mouths or feet of infected animals.

Is vesicular stomatitis contagious to humans?

Vesicular Stomatitis (VS) is a contagious disease that afflicts horses, livestock, wildlife and even humans.

What is equine vesicular stomatitis?

Vesicular Stomatitis (VS) is a contagious disease that afflicts horses, livestock, wildlife and even humans. The disease is caused by a virus, which although rarely life threatening, can have significant financial impact on the horse industry.

Is vesicular stomatitis treatable?

No specific treatment is needed. When infected animals are identified, they should be isolated until the disease has run its course. Other animals on the property should be restricted to the property to reduce the chance of the disease spreading.

How do you prevent vesicular stomatitis?

Vesicular Stomatitis In Humans Precautions should include wearing latex gloves and avoiding direct contact with the horse’s saliva or blister fluids. Special care should be taken to keep mouth, eyes and any open wounds from being exposed to infection.

How is vesicular stomatitis diagnosed?

Diagnosis is based on the presence of typical signs and either antibody detection through serologic tests, viral detection through isolation, or detection of viral genetic material by molecular techniques. Samples for viral isolation may include vesicular fluid, epithelial tags from lesions, or swabs of lesions.

What states have vesicular stomatitis?

Vesicular stomatitis virus (VSV), a reportable animal disease, has been found in seven states in 2020: Arizona, Kansas, Missouri, Nebraska, New Mexico, Oklahoma and Texas. As VSV may spread throughout the Midwest and mountain states, livestock owners, especially those with horses, should be looking for symptoms.

What is the structure of the VSV nucleocapsid particle?

Structures of the nucleocapsid-like particles (NLPs) of VSV and rabies virus have recently been solved ( 4, 5 ), showing that the N protein has 2 lobes angled together to form a cavity for encapsidation of the genomic RNA. Each N monomer accommodates 9 bases of RNA.

Which is nucleocapsid binds to the NSRV P?

Here, we present the X-ray crystal structure of the C-terminal domain of P of vesicular stomatitis virus, a prototypic nonsegmented NSRV, bound to nucleocapsid-like particles. P binds primarily to the C-terminal lobe of 2 adjacent N proteins within the nucleocapsid.

What kind of virus is vesicular stomatitis virus?

Vesicular stomatitis virus (VSV) belongs to the family Rhabdoviridae, which also includes rabies virus. The rhabdoviruses are part of the broad group of negative-strand RNA viruses (NSRVs), which contain many medically relevant viruses, including avian influenza, measles, and Ebola.

What are the genes of the VSV virus?

VSV has long served as a prototypic nonsegmented negative-strand RNA virus (NNSRV), partly because of the small number of genes that are encoded by its 11-kb genome ( 1 ). These genes include the nucleocapsid protein (N), a phosphoprotein (P), a matrix protein (M), a glycoprotein (G), and a large polymerase protein (L).