Which ethnic groups are most likely to have the Alu insertion?

Alu diversity is highest in Africans (0.349) and lowest in Europeans (0.297). Alu insertion frequency is lowest in Africans (0.463) and higher in Indians (0.544), E. Asians (0.557), and Europeans (0.559). Large genetic distances are observed among African populations and between African and non-African populations.

What is Alu PV92?

Alu is a transposon Because transposons tend to get duplicated, they can occur many times in an organism’s genome, and because they tend to get inserted at new locations, these repeated DNA sequences can be scattered throughout the genome.

What are the three possible genotypes for Alu?

The three genotypes being investigated are homozygous positive, (++) which has the Alu insert present on both alleles, heterozygous (+-) which has the Alu insert present on one allele and not the other, and finally homozygous negative (- -) which is lacking the Alu insert on both alleles.

What is Alu PV92 and how can someone determine their genotype for it?

PV92 is a human-specific Alu insertion on chromosome 16. The PV92 genetic system has only two alleles indicating the presence (+) or absence (-) of the Alu transposable element on each of the paired chromosomes. This results in three PV92 genotypes (++, +-, or –).

How are Alu elements separated in the PV92 genetic system?

The PV92 genetic system has only two alleles indicating the presence (+) or absence (-) of the Alu transposable element on each of the paired chromosomes. This results in three PV92 genotypes (++, +-, or –). The + and – alleles can be separated by size using gel electrophoresis. Alu elements are classified as SINEs, or Short INterspersed Elements.

How many alleles are there in the PV92 genetic system?

The PV92 genetic system has only two alleles indicating the presence (+) or absence (-) of the Alu transposable element on each of the paired chromosomes. This results in three PV92 genotypes (++, +-, or –). The + and – alleles can be separated by size using gel electrophoresis.

Where are Alu elements found in the human genome?

In genetics, the presence or lack thereof of a recently inserted Alu element may be a good property to consider when studying human evolution. Most human Alu element insertions can be found in the corresponding positions in the genomes of other primates, but about 7,000 Alu insertions are unique to humans.

Is there an Alu repeat in the PV92 locus?

Everybody has the PV92 locus, but some people have an extra stretch of repetitive DNA (called an Alu repeat) in it. The ALU repeat is a stretch of 300 nucleotides that occurs over and over at various locations in the human genome.