Which blood thinner is best for factor V Leiden?

Apixaban (Eliquis): Apixaban is indicated for the treatment of DVT and PE and for reduction of the risk of recurrent DVT and PE following initial therapy. It does not require renal or hepatic dose adjustments for impairment.

What is the difference between Factor 5 and Factor 5 Leiden?

Factor V Leiden is a completely different inherited disorder in which factor V is mutated in a specific gene, which results in a hypercoagulable state. The mutation is very common, occurring in 5% of the US population. Factor V activity levels in patients with factor V Leiden are usually normal.

What is factor V Leiden genotype?

Overview. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Most people with factor V Leiden never develop abnormal clots.

Can factor V Leiden be cured?

Management and Treatment The factor V Leiden mutation itself does not have any specific treatment. But when a person is diagnosed with an acute deep vein thrombosis (DVT) or pulmonary emblolism (PE), treatment with anticoagulants (blood thinners) will be necessary and should be started as soon as possible.

Can you donate blood if you have Factor 5 Leiden?

People with factor V Leiden may donate blood, platelets or plasma safely, as long as they are not on an anticoagulant such as warfarin. Only a very few medicines prevent people from donating blood.

Should I take aspirin if I have factor V Leiden?

Though factor V Leiden alone does not seem to raise the risk of arterial clots, something as simple as daily therapy with low-dose aspirin may help prevent a heart attack or stroke in people with factor V Leiden if they have additional risk factors.

Can you give blood if you have Factor 5 Leiden?

What does it mean if you are heterozygous for factor V Leiden?

Heterozygous means that the 2 copies of a gene are different. In your case, one of your Factor V gene codes is for normal clotting Factor V and the other Factor V gene code is for Factor V Leiden. There is more risk of a blood clot if both gene codes are for Factor V Leiden (ie in the homozygous state).

Can I donate platelets if I have Factor V Leiden?

What percentage of the population has factor V Leiden?

Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of people with European ancestry carry one copy of the factor V Leiden mutation in each cell, and about 1 in 5,000 people have two copies of the mutation. The mutation is less common in other populations.

Does Factor 5 skip generations?

Factor V deficiency is an inherited bleeding disorder that can cause excessive bleeding. Can Factor V Leiden skip a generation? No… genetic mutations are passed from generation to generation because we receive our DNA from our parents.

Can I donate platelets if I have factor V Leiden?

Is there a cure for factor V Leiden?

No. Factor V is a genetic mutation with no known cure. No, but there is treatment with anticoagulant medication. There is no known cure for Factor V Leiden at this time because it is a gene mutation and it is in your DNA.

How does the Leiden mutation affect factor V?

The mutation results to Factor V responding more gradually to Protein C. Protein C is an anti-clotting aspect that usually controls Factor V activity. Consequently, individuals with Factor V Leiden mutation have increased risks of thrombophilia or blood clots.

Where does factor V Leiden thrombophilia come from?

Inheritance. We inherit one copy from our mother and the other from our father. As a result, our risk for having factor V Leiden thrombophilia depends on the genetic status of each of our parents. Most people with factor V Leiden thrombophilia have one “normal” F5 gene and one with the factor V Leiden gene mutation.

Why does APC not inactivate Factor V Leiden?

In people with the factor V Leiden mutation, APC is unable to inactivate factor V normally. As a result, the clotting process continues longer than usual, increasing the chance of developing abnormal blood clots. What are the symptoms of factor V Leiden thrombophilia?