What type of drug is etoposide?

Etoposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.

What is etoposide mechanism of action?

Etoposide (VP-16). Its mechanism of action is to cause single-strand and double-strand breaks in DNA through interaction with DNA topoisomerase II, inducing arrest in the G2-phase of the cell cycle [8,21,154]. This activity is mediated through the formation of a stable complex with DNA and topoisomerase II.

What is the generic name for etoposide?

VePesid and etopophos and toposar or etoposide phosphate are other names for etoposide. In some cases, health care professionals may use the trade name VP-16 or other names VePesid or etopophos or toposar or etoposide phosphate when referring to the generic drug name etoposide.

How does etoposide treat cancer?

Etoposide works by blocking the action of an enzyme in cells called topoisomerase, which is necessary for cell replication and tumor growth. Cells need this enzyme to keep their DNA in the proper shape when they are dividing. Blocking this enzyme leads to breaks in the DNA, which leads to cancer cell death.

What conditions does etoposide treat?

Etoposide is used to treat certain forms of lung cancer (such as small cell lung cancer ). Etoposide works by slowing the growth of cancer cells. Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment.

How is etoposide administered?

Etoposide is a prescription chemotherapy medication. It comes in the form of a capsule that is taken by mouth and as an injection (Toposar ®) that is given intravenously (by IV).

Is etoposide carcinogenic to humans?

Human carcinogen — Etoposide: Etoposide is deemed to be carcinogenic to humans. The carcinogenicity of the substance may be influenced by the duration and level of exposure.