What is the pathogenesis of osteoarthritis?

The pathogenesis of OA involves a degradation of cartilage and remodelling of bone due to an active response of chondrocytes in the articular cartilage and the inflammatory cells in the surrounding tissues.

Is osteoarthritis inflammatory in origin?

Noninflammatory arthritis, such as osteoarthritis (OA), can also cause inflammation. However, this inflammation typically results from normal wear and tear to the joints.

How does inflammation contribute to the progression of osteoarthritis?

A systematic review published in May 2015 stated, “Human osteoarthritis is a systemic musculoskeletal disorder involving activation of innate and adaptive immune systems accompanied by inflammation exemplified by the elevated production of proinflammatory cytokines, which play a significant role in the progression of …

Is OA an inflammatory disease?

Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however, the dichotomy between inflammatory and degenerative arthritis is becoming less clear with the recognition of a plethora of ongoing immune processes within the OA joint and synovium.

Why are there osteophytes in OA?

OA develops as we age or after damage (like a sports injury). As the body tries to repair cartilage, it creates new bone material. These new bony growths are osteophytes. Ankylosing spondylitis also may cause bone spurs.

Do eggs worsen arthritis?

Consuming eggs regularly can lead to an increased amount of swelling and joint pain. The yolks contain arachidonic acid, which helps trigger inflammation in the body. Eggs also contain saturated fat which can also induce joint pain.

Is osteoarthritis inflammatory or noninflammatory?

Osteoarthritis is a non-inflammatory disease that causes cartilage — the spongy substance that cushions the space between bones — to deteriorate.

Is synovitis present in osteoarthritis?

Synovitis is common in osteoarthritis, new research shows. The study suggests the need for a shift in treatment paradigms that target structural disease progression rather than just alleviating pain.

Is there evidence that OA is an inflammatory disease?

There is accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial joint and has multiple phenotypes. This presents the OA research community with new challenges and opportunities. The main challenge is to understand the root cause of the disease and identify differences and similarities between OA phenotypes.

Is the synthesis of IL-1ß upregulated in osteoarthritis?

Synthesis of IL-1ß and TNF-, as well as their membrane-bound receptors, is upregulated in osteoarthritis.

What are the risk factors for osteoarthritis ( OA )?

OA is caused by damage or breakdown of joint cartilage between bones. What are the risk factors for OA? Joint injury or overuse—Injury or overuse, such as knee bending and repetitive stress on a joint, can damage a joint and increase the risk of OA in that joint. Age—The risk of developing OA increases with age.

What is the new framework for osteoarthritis etiology?

The new framework for osteoarthritis etiology permits us to classify these factors either as drivers of abnormal stresses on articular cartilage, including obesity, anatomic abnormalities, or trauma; or as drivers of aberrant cartilage physiology, including aging, genetic and metabolic factors, and inflammation (Figure 1).