What is structure of cisplatin?
What is structure of cisplatin?
[Pt(NH3)2Cl2]
Cisplatin/Formula
How many atoms of ammonia and platinum are in cisplatin?
Cisplatin contains a platinum atom complexed with two ammonia groups and two chlorides residue, and carboplatin contains a platinum atom complexed with two ammonia groups and 1,1-cyclobutane-dicarboxyl residue.
What elements are present in cisplatin?
Cisplatin
| PubChem CID | 5702198 |
|---|---|
| Molecular Formula | PtCl2(NH3)2 or Cl2H6N2Pt |
| Synonyms | cisplatin 14913-33-8 trans-Dichlorodiamineplatinum(II) azane;dichloroplatinum Platinum, diamminedichloro-, (SP-4-1)- More… |
| Molecular Weight | 300.05 |
| Component Compounds | CID 222 (Ammonia) CID 2770 (Platinum(II) chloride) |
What is the mechanism of action of cisplatin?
The current accepted paradigm about cisplatin mechanism of action is that the drug induces its cytotoxic properties through binding to nuclear DNA and subsequent interference with normal transcription, and/or DNA replication mechanisms.
Is cisplatin a strong chemo drug?
Cisplatin is a potent chemotherapeutic drug that has shown efficacy for the treatment of many malignancies including head and neck, ovarian, sarcomas, lymphoma, and prostate cancer.
Does cisplatin cause hair loss?
v Hair loss is minimal with cisplatin, but some patients do experience more hair loss than others. Hair growth should return upon completion of treatment.
What does cisplatin do to the DNA?
Cisplatin interacts with DNA mainly in the form of Pt-d(GpG) di-adduct, which stalls cell proliferation and activates DNA damage response. Although cisplatin shows a broad spectrum of anticancer activity, its utility is limited due to acquired drug resistance and toxicity to non-targeted tissues.
How does cisplatin damage DNA?
Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death. The 1,2-intrastrand cross-links of purine bases with cisplatin are the most notable among the changes in DNA.
Why is cisplatin so toxic?
Renal toxicity from cisplatin derives from the uptake and activation of platinum within the proximal tubule cell. Therefore, maneuvers which differentially reduce cisplatin uptake, or activation by the kidney relative to tumor cells, should reduce nephrotoxicity without impairing anti-tumor responses.
Will I lose my hair on cisplatin?
How long does cisplatin stay in the body?
The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.
What kind of chemical compound is cisplatin II?
Cisplatin (CAS no. 15663-27-1, MF-Cl2 H 6 N 2 Pt; NCF-119875), cisplatinum, also called cis -diamminedichloroplatinum (II), is a metallic (platinum) coordination compound with a square planar geometry ( The chemical book database, 2014 ). It is a white or deep yellow to yellow–orange crystalline powder at room temperature.
What is the molecular formula for cis platin?
cis-Platin PubChem CID 441203 Structure Find Similar Structures Molecular Formula Cl2H6N2Pt+2 Synonyms cis-Platin cis-DDP Cisplatine Cisplatino Molecular Weight 300.0
How does the platinum complex in cisplatin work?
The way that cisplatin operates is by forming a platinum complex inside of a cell which binds to DNA. When DNA is cross-linked in this manner, the cell undergoes apoptosis, or systemic cell death.
How is cisplatin used in the treatment of cancer?
Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury.