What is normal Mentzer index?

Diagnostic Considerations Calculation of the Mentzer index (mean corpuscular volume per red cell count) may be helpful. A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency.

Is Mentzer index accurate?

The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting β-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.

What is the normal range of thalassemia?

Thalassemia intermedia is characterized by Hb level between 7 and 10 g/dl, MCV between 50 and 80 fl and MCH between 16 and 24 pg. Thalassemia minor is characterized by reduced MCV and MCH, with increased Hb A2 level [29].

How can you tell the difference between iron deficiency and thalassemia?

Distinguishing Iron Deficiency Anemia From Thalassemia Trait The first difference is in the red blood cell count (labeled RBC). In iron deficiency, this value is low because the bone marrow is unable to manufacture red blood cells. In thalassemia trait, RBC is normal to elevated.

How is Mentzer calculated?

The index is calculated from the results of a complete blood count. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia is said to be more likely.

What is Sehgal index?

Sehgal index is a new index used in this study, and it was calculated as follows – Sehgal index = MCV × MCV/RBC. Results. We evaluated 1022 cases and 973 cases of suspected hemoglobinopathies in Phase 1 and Phase 2, respectively.

When do you use Mentzer index?

The Mentzer index, described in 1973 by William C. Mentzer, is the MCV divided by the RBC count. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia. The index is calculated from the results of a complete blood count.

How can you tell the difference between thalassemia?

The diagnosis of beta thalassemia is generally made using High Performance Liquid Chromatography (HPLC) or Capillary Zone Electrophoresis (CZE), while alpha thalassemia can be diagnosed using a phenotypic method (a special stain of the peripheral blood smear) or a genotypic method which identifies the common mutations …

Is thalassemia related to iron deficiency?

It has long been considered that iron deficiency does not exist in thalassemia syndromes, including thalassemia major as well as trait. However, studies have shown the occurrence of iron deficiency in patients with beta thalassemia trait (BTT).

What is thalassemia trait?

Overview. Thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued. If you have mild thalassemia, you might not need treatment.

What is the purpose of the Mentzer index?

Mentzer index. The Mentzer index is used to differentiate iron deficiency anemia from beta thalassemia. It is calculated from the results of a complete blood count.

How to calculate the Mentzer index of blood?

Mentzer index = MCV ÷ RBC. Where, MCV = Mean corpuscular volume , RBC = Red blood cell.

How is the Mentzer index used to diagnose iron deficiency?

Mentzer index. The Mentzer index is used to differentiate iron deficiency anemia from beta thalassemia. It is calculated from the results of a complete blood count. If the quotient of the mean corpuscular volume divided by the red blood cell count is less than 13, thalassemia is more likely.

How is the Mentzer index of thalassemia calculated?

The index is calculated from the results of a complete blood count. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia is said to be more likely. If the result is greater than 13, then iron-deficiency anemia is said…